GROWTH HORMONE DOSE-RESPONSE RELATIONSHIPS

生长激素剂量-反应关系

• 批准号: 3849177
• 负责人: ROBERT DANISH
• 金额: --
• 依托单位: UNIVERSITY HOSPITALS OF CLEVELAND
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3849177
• 关键词: Turner's syndrome; body height; child (0-11); endocrine disorder; endocrine disorder diagnosis; hormone regulation /control mechanism; human subject; somatotropin

The aim of this proposal is to define the growth hormone (GH) dose-response relationships in children having short stature of various causes (classical GH deficiency, normal short stature, Turner's syndrome, and unclassified short stature). The intent is to examine whether differences in GH dose-responsiveness actually exist between GH deficient and GH sufficient subjects, and whether these differences could be utilized for diagnostic test purposes.

该提案的目的是定义生长激素（GH） 在各种身材矮小的儿童中的剂量-反应关系 原因（经典GH缺乏症，正常身材矮小，特纳氏 综合征和未分类的身材矮小）。 目的是检查 GH剂量反应性的差异是否真的存在于GH 缺乏和GH充足的受试者，以及这些差异是否 可用于诊断测试目的。