LIVER BIOPSY STUDY AFTER METHOTREXATE THERAPY IN RHEUMATOID ARTHRITIS PATIENTS

类风湿关节炎患者甲氨蝶呤治疗后的肝活检研究

• 批准号: 3740684
• 负责人: DANIEL O CLEGG
• 金额: --
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3740684
• 关键词: biopsy; dosage; drug adverse effect; drug screening /evaluation; fibrosis; hepatotoxin; human subject; human therapy evaluation; liver disorder; liver disorder diagnosis; liver function; methotrexate; rheumatoid arthritis; skeletal disorder chemotherapy

Methotrexate has been shown to be an effective "slow-acting" drug for treatment of refractory arthritis. We will determine whether patients on low dose pulse methotrexate develop liver disease that is not detected from routine liver function tests. There is some evidence that hepatic fibrosis can be found in such patients.

甲氨蝶呤已被证明是一种有效的慢作用药物 顽固性关节炎的治疗。我们将确定患者是否 小剂量脉冲甲氨蝶呤会发展成未被检测到的肝病 从常规的肝功能测试。有一些证据表明，肝脏 在这类患者中可以发现纤维化。