CLINICAL INVESTIGATIONS AND CASE REPORTS

临床研究和病例报告

• 批准号: 3854192
• 负责人: J C ATKINSON
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3854192
• 关键词: aplastic anemia; autosomal recessive trait; case history; child (0-11); dental disorder; dental disorder chemotherapy; dental disorder diagnosis; dental radiography; dental research; endosseous dental implant; genetic disorder; human subject; human therapy evaluation; interview; mandible /maxilla; oral health; periodontium disorder; xeroderma pigmentosum

Clinical case studies of unusual interest and clinically related research are being conducted on a variety of dentally related subjects. Research techniques being utilized include chart and literature reviews, and evaluation of various therapeutic regimens. A recent case study documented the use of oral endosseous titanium implants to replace the mandibular teeth of a patient with Erdheim-Chester (E-C) disease. The patient lost all teeth due to rapidly progressing periodontal disease related to fatty infiltration of bone marrow tissue associated with this condition. Oral implants were utilized to replace the lost mandibular teeth. Despite the abnormal marrow tissue present in the E-C patient, the implants are functioning successfully. Another case study is documenting the use of endosseous dental implants in an edentulous patient with Papillon-Lefevre syndrome, which is also referred to as generalized juvenile periodontosis. This condition can cause the early loss of the permanent teeth due to rapid bone destruction of unknown etiology. The use of endosseous implants in patients with this syndrome has been questioned because of the possibility of rapid bone loss around implants similar to that which occurs around the natural teeth. Four mandibular endosseous implants have successfully integrated in this patient. The maxillae is being treated with a combination of bone grafting and endosseous implants. Chart reviews and clinical examinations were also used to document oral conditions associated with Xeroderma pigmentosum and Aplastic anemia.

不寻常的兴趣和临床相关的临床病例研究 目前正在对各种与牙齿有关的主题进行研究。 正在使用的研究技术包括图表和文献综述， 和各种治疗方案的评价。 最近一项案例研究 记录了使用口腔骨内钛种植体来替代 Erdheim-Chester（E-C）病患者的下颌牙。 的 患者由于牙周病快速进展而失去所有牙齿 与骨髓组织的脂肪浸润有关， 条件 口腔种植体被用来取代失去的下颌骨 牙齿. 尽管E-C患者存在异常的骨髓组织， 植入物功能正常 另一个案例研究是 记录无牙颌患者骨内牙种植体的使用 患有Papillon-Lefevre综合征的患者，也被称为 全身性青少年牙周炎 这种情况可能会导致早期 由于不明原因的快速骨破坏而导致的恒牙缺失 病因学 骨内植入物在该综合征患者中的应用 一直受到质疑，因为周围的快速骨质流失的可能性 类似于天然牙齿周围的植入物。 四 下颌骨骨内种植体已成功地整合在这个 病人 他的上颌骨正在接受一种 移植和骨内植入物。 病历审查和临床 检查也被用来记录口腔条件相关的 着色性干皮病和再生障碍性贫血。