ORAL HEALTH AND SALIVARY FUNCTION IN HIV-1 INFECTED PATIENTS

HIV-1 感染患者的口腔健康和唾液功能

• 批准号: 3839234
• 负责人: J C ATKINSON
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3839234
• 关键词: HIV infections; Mycoplasma; Sjogren's syndrome; adult human (21+); antinuclear autoantibody; antiviral agents; child (0-11); dental caries; gingivitis; human immunodeficiency virus 1; human subject; microorganism culture; oral bacteria; oral health; pediatric AIDS; periodontitis; saliva; salivary disorder; salivary glands; tissue /cell culture; yeasts

This project focuses on oral changes associated with HIV-1 infection. We h e examined saliva and salivary glands, critical components of the oral defense system, or changes following infection. Forty-four percent of patients with HIV-associated sal ary gland disease (HIV-SGD) had salivary antibodies that recognized the cytoplasm of human salivary epithelial cell line, but the autoantibodies were not anti-SS-A, a i-SS-B, or anti-DNA. In contrast, 73% of patients with primary Sjogren's syndrome had nti-SS-A or anti-SS-B in their saliva. Periodontal status in approximately 200 HIV-1 se positive patients was assessed (see Z01-DE-000498-03). HIV-associated periodontitis s not found, and HIV-associated gingivitis was more common. The subgingival flora of 39 these subjects with gingivitis or adult periodontitis was cultured quantitatively In general, the same types of bacteria were isolated as from the subgingiva of non-HIV bjects. Mycoplasma salivarium was significantly elevated in the HIV+ subjects exami d. Yeasts were isolated from only 10% of the samples. Pediatric patients with HIV-1 fection appear to have normal dental development, and one-third of the patients ref red for dental care have nursing bottle caries. Data suggest that saliva likely has everal means by which to inhibit HIV-1 infectivity.

该项目的重点是与HIV-1感染有关的口腔变化。 我们 e审查 唾液和唾液腺，口腔防御系统的关键组成部分， 或改变 感染后。44%的艾滋病相关性肉瘤患者 腺 疾病（HIV-SGD）的唾液抗体识别的细胞质， 人类 唾液腺上皮细胞系，但自身抗体不是抗SS-A， i-SS-B，或 反DNA 相反，73%的原发性干燥综合征患者 nti-SS-A或 唾液中有抗SS-B抗体约200例HIV-1感染者的牙周炎状态 积极 对患者进行了评估（参见Z 01-DE-000498-03）。HIV相关性牙周炎 未找到% s， HIV相关性牙龈炎更为常见。龈下植物群共39个 这些 对牙龈炎或成人牙周炎患者进行定量培养 总的来说， 从非HIV感染者的龈下分离出相同类型的细菌， 很好。 唾液支原体在HIV阳性受试者中显著升高， D.酵母 只从10%的样本中分离出来 HIV-1儿童患者 感染 似乎有正常的牙齿发育，三分之一的患者参考 色系色号供 牙齿护理有奶瓶龋。数据显示，唾液可能 几种方法 从而抑制HIV-1的传染性。