ORAL HEALTH AND SALIVARY FUNCTION IN HIV-1 INFECTED PATIENTS

这个项目的重点是与HIV-1感染相关的口腔变化。我们有 E已审核 唾液和唾液腺，口腔防御系统的关键组成部分， 或改变 在感染之后。44%的HIV相关销售患者 阿瑞腺 疾病(HIV-SGD)具有识别细胞质的唾液抗体 人类 唾液上皮细胞株，但自身抗体不是抗SS-A，a I-SS-B，或 抗DNA抗体。相比之下，73%的原发性干燥综合征患者 NTI-SS-A或 唾液中含有抗SS-B抗体。约200例HIV-1感染者的牙周状况 积极的 对患者进行评估(见Z01-DE-000498-03)。HIV相关性牙周炎 找不到S， 而与艾滋病毒相关的牙周炎更常见。39例牙周炎患者的龈下菌群 这些 对患有牙周炎或成人牙周炎的受试者进行定量培养 总体而言, 从非HIV患者的牙周组织中分离出了相同类型的细菌 客体。 HIV阳性受试者唾液支原体显著升高 D.酵母菌 仅从10%的样本中分离出。儿童HIV-1感染者 感染 看起来牙齿发育正常，三分之一的患者 红色代表 牙科护理有奶瓶龋齿。数据表明，唾液可能有 各种手段 通过它来抑制HIV-1的传染性。

This project focuses on oral changes associated with HIV-1 infection. We h e examined saliva and salivary glands, critical components of the oral defense system, or changes following infection. Forty-four percent of patients with HIV-associated sal ary gland disease (HIV-SGD) had salivary antibodies that recognized the cytoplasm of human salivary epithelial cell line, but the autoantibodies were not anti-SS-A, a i-SS-B, or anti-DNA. In contrast, 73% of patients with primary Sjogren's syndrome had nti-SS-A or anti-SS-B in their saliva. Periodontal status in approximately 200 HIV-1 se positive patients was assessed (see Z01-DE-000498-03). HIV-associated periodontitis s not found, and HIV-associated gingivitis was more common. The subgingival flora of 39 these subjects with gingivitis or adult periodontitis was cultured quantitatively In general, the same types of bacteria were isolated as from the subgingiva of non-HIV bjects. Mycoplasma salivarium was significantly elevated in the HIV+ subjects exami d. Yeasts were isolated from only 10% of the samples. Pediatric patients with HIV-1 fection appear to have normal dental development, and one-third of the patients ref red for dental care have nursing bottle caries. Data suggest that saliva likely has everal means by which to inhibit HIV-1 infectivity.