ORAL HEALTH AND SALIVARY FUNCTION IN HIV-1 INFECTED PATIENTS

HIV-1 感染患者的口腔健康和唾液功能

• 批准号: 3875266
• 负责人: J C ATKINSON
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3875266
• 关键词: AIDS; HIV infections; Sjogren's syndrome; gingivitis; human immunodeficiency virus 1; human middle age (35-64); human old age (65+); human subject; human very old age (85+); immunoglobulin A; lactoferrin; longitudinal human study; lysozyme; oral health; periodontitis; rheumatoid factor; saliva; salivary disorder; salivary glands; submandibular gland

This project focuses on oral changes associated with HIV-1 infection. We have examined saliva, a critical part of the oral defense system, for changes following infection in cross-sectional and longitudinal studies. In all studies, the antimicrobial proteins lactoferrin, lysozyme, histatins, and salivary IgA were elevated in males positive for HIV-1 antibody. Of these proteins, only lysozyme continued to increase with time. Changes were most dramatic in the stimulated submandibular saliva. Salivary secretions from HIV-1 positive patients with a salivary gland enlargement which mimics that seen in Sjogren's syndrome were analyzed. Higher elevations of salivary IgA, lactoferrin, and IgA rheumatoid factor (RF) were present in HIV-1 positive patients with salivary gland enlargement than in HIV-1 positive patients with no enlargement. However, the saliva from patients with primary Sjogren's syndrome had much higher levels of salivary IgA, lactoferrin, and IgA RF. Recently, a study has started to examine periodontal status associated with HIV-1 infection (also see Z01 DE 00498-01). Preliminary data suggest that HIV-associated periodontitis is not frequently seen, and HIV-associated gingivitis is more common. These studies hope to establish a logical rationale for treatment of the oral problems seen in AIDS. We have also examined the incidence of AIDS among older persons, and observed that greater than 10% of cases in the U.S. occur in patients aged 50 years or older.

这个项目的重点是与HIV-1感染相关的口腔变化。我们 已经检查了唾液，口腔防御系统的关键部分， 横断面和纵向研究中感染后的变化。在……里面 所有的研究，抗菌蛋白乳铁蛋白，溶菌酶，组他汀类， HIV-1抗体阳性者唾液IgA升高。的 这些蛋白质中，只有溶菌酶随着时间的推移不断增加。变化是 最具戏剧性的是刺激的下颌下唾液。唾液分泌物 来自HIV-1阳性患者的唾液腺肿大 对干燥综合征的临床表现进行了分析。更高的海拔 唾液中存在IgA、乳铁蛋白和IgA类风湿因子(RF)。 HIV-1阳性患者唾液腺比HIV-1患者大 阳性患者无肿大。然而，患者的唾液 患有原发性干燥综合征的患者唾液中IgA水平要高得多， 乳铁蛋白和IgA RF。最近，一项研究已经开始检查 与HIV-1感染相关的牙周状态(另见Z01 DE 00498-01年度)。初步数据显示，艾滋病毒相关的牙周炎 并不常见，与HIV相关的牙周炎较为常见。这些 研究希望为口腔治疗建立一个合理的理论基础 在艾滋病中看到的问题。我们还调查了以下人群中艾滋病的发病率 并观察到，在美国，超过10%的病例。 发生在50岁或以上的患者。