Life Study: Phase 1

生命研究：第一阶段

• 批准号: ES/L012871/1
• 负责人: Carol Dezateux
• 金额: $ 1786.36万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ES%2FL012871%2F1
• 关键词: Life; Study; Phase

A birth cohort study follows the same babies throughout their lives to understand more about how a child's very early social, emotional and physical development and their family and wider environment influences their future development, health and well-being as well as their risk of future ill health. These special types of studies give insights into what is called the life course starting in early life - they are a unique and special way to find out how early life experiences matter for later childhood and adult life. Our study will help identify what aspects of the environment in its broadest sense protect children and maximise their life chances and the ways in which that protection operates. It will also help us understand what aspects may increase vulnerability. We wish to understand the interplay between environmental and biological influences in early life recognising that this needs understanding of parents' lives and the wider family and society too.We plan to invite around 80,000 pregnant women and their partners from across the UK to join our study, around 60,000 in pregnancy and 20,000 after the birth of their baby. We want to include women and their partners from all walks of life. We will work to maximise recruitment of people from different ethnic groups. In pregnancy both parents will be interviewed, weighed and measured and asked to take part in some simple computer based tests. Parents will be asked to bring their baby to be seen at 6 and 12 months of age for some body size measurements and eye and child development tests. There will be no blood tests for the baby. In the first phase of Life Study we will work with two maternity units to offer mothers and their partners an opportunity to take part, aiming to recruit around 16,000 mothers in pregnancy and we will also recruit about 10,000 mothers in the early months after the birth of their baby. Our experience in this first phase will help us refine the second phase when we plan to recruit the remaining 54,000 mothers (44,000 in pregnancy and 10,000 after birth).We hope to follow all the children and their families throughout childhood and adult life so that we can see how they grow and develop and how their family circumstances change. We will do that in a number of ways including by getting consent at the beginning of the study to link to future routine health and other records of the baby and parents/care-givers. Scientists and others learn a lot from these large studies about how we can help children get a good start in life and improve their life chances and future well being and happiness. The information collected will be anonymised so that the privacy of families can be protected and will be made available to researchers to analyse to make sure we get the most benefit from it. We will be able to compare the Life Study generation with information collected from earlier generations in similar special British cohort studies.We will make sure that families taking part are informed about the progress of the study and any early findings and will ensure that other scientists, in the UK and abroad, policymakers and all members of the public also get to hear about Life Study findings. We have been working with members of the public from a wide range of backgrounds to help us plan the Study and ensure that it can answer questions that parents think are important.

一项出生队列研究跟踪了这些婴儿的一生，以更多地了解孩子早期的社会、情感和身体发育，以及他们的家庭和更广泛的环境如何影响他们未来的发展、健康和福祉，以及他们未来患病的风险。这些特殊类型的研究让我们深入了解所谓的从生命早期开始的生命历程——它们是一种独特而特殊的方式，可以发现早期生活经历对后来的童年和成年生活有何影响。我们的研究将有助于确定环境的哪些方面在最广泛的意义上保护儿童，最大限度地提高他们的生活机会，以及这种保护的运作方式。它还将帮助我们了解哪些方面可能会增加脆弱性。我们希望了解早期生活中环境和生物影响之间的相互作用，认识到这需要了解父母的生活以及更广泛的家庭和社会。我们计划邀请来自英国各地的约8万名孕妇及其伴侣加入我们的研究，其中约6万名孕妇和2万名产后孕妇。我们希望包括各行各业的女性和她们的伴侣。我们会尽量聘用不同族裔的人才。在怀孕期间，父母双方都将接受采访，称重和测量，并要求参加一些简单的基于计算机的测试。父母将被要求在孩子6个月和12个月大的时候带着他们来做一些身体尺寸测量、眼睛和儿童发育测试。不会对婴儿进行血液检查。在生命研究的第一阶段，我们将与两个产科单位合作，为母亲及其伴侣提供参与的机会，目标是招募约16,000名怀孕的母亲，我们还将招募约10,000名婴儿出生后最初几个月的母亲。我们在第一阶段的经验将帮助我们完善第二阶段，届时我们计划招募剩余的54,000名母亲（44,000名孕期母亲和10,000名产后母亲）。我们希望跟踪所有的孩子和他们的家庭，从童年到成年，这样我们就可以看到他们是如何成长和发展的，以及他们的家庭环境是如何变化的。我们将通过多种方式做到这一点，包括在研究开始时征得同意，将未来的常规健康和婴儿及父母/照顾者的其他记录联系起来。科学家和其他人从这些大型研究中学到了很多关于我们如何帮助孩子们有一个良好的生活开端，提高他们的生活机会和未来的幸福和幸福。收集到的信息将被匿名化，以保护家庭的隐私，并将提供给研究人员进行分析，以确保我们从中获得最大的利益。我们将能够将生命研究一代与从早期英国类似的特殊队列研究中收集的信息进行比较。我们将确保参与研究的家庭了解研究的进展和任何早期发现，并确保英国和国外的其他科学家、政策制定者和所有公众成员也能听到生命研究的发现。我们一直在与来自不同背景的公众合作，帮助我们计划这项研究，并确保它能回答家长认为重要的问题。

项目成果

Life Study Pregnancy component mother consent form

生命研究怀孕部分母亲同意书

• DOI: 10.14324/000.wp.1485705
• 作者: Dezateux C

Life Study Birth Component: Non-resident Father questionnaire

生活研究出生部分：非居民父亲问卷

• DOI: 10.14324/000.wp.1485692
• 作者: Dezateux C

Life Study: Birth Component: Pilot: Face-to-face fieldwork

生活研究：出生部分：试点：面对面实地考察

• DOI: 10.14324/000.rp.1485697
• 作者: Clemens S

Life Study Birth component father/partner consent form

生命研究 出生成分 父亲/伴侣同意书

• DOI: 10.14324/000.wp.1485689
• 作者: Dezateux C

Life Study Birth component non-resident father consent form

生活研究 出生部分 非居民父亲同意书

• DOI: 10.14324/000.wp.1485687
• 作者: Dezateux C