Defining the contribution of A-to-I RNA editing by ADAR’s in physiology and disease

定义 ADAR 的 A 到 I RNA 编辑在生理学和疾病中的贡献

• 批准号: nhmrc : 1144049
• 负责人: A/Pr Carl Walkley
• 金额: $ 49.23万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-contribution-a-physiology-disease/1320109
• 关键词: Defining; contribution; RNA; editing; ADAR

We are working on understanding how a family of proteins called ADARs work. ADAR proteins can change the sequence of the cells RNA. When they are mutated or more than normal amounts are expressed in a cell it appears they can cause a range of diseases in humans. We are trying to determine how changes in the level or activity of ADAR proteins may contribute to disease.

我们正在努力了解一个叫做ADAR的蛋白质家族是如何工作的。阿达尔蛋白可以改变细胞RNA的序列。当它们发生突变或在细胞中表达超过正常量时，它们可能会导致人类一系列疾病。我们正试图确定阿达尔蛋白水平或活性的变化如何导致疾病。