Microenvironmental regulation of blood cells by retinoic acid receptor gamma.

视黄酸受体γ对血细胞微环境的调节。

• 批准号: nhmrc : GNT1127551
• 负责人: A/Pr Carl Walkley
• 金额: $ 95.84万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microenvironmental-regulation-blood-receptor-gamma/1347632
• 关键词: Microenvironmental; regulation; blood; cells; retinoic

Vitamin A deficiency causes profound effects in humans, with anaemia and an inability to fight infection being consequences of vitamin A deficiency on blood cells. We have evidence that these effects of vitamin A deficiency occur via one of the receptors for vitamin A. Furthermore, these effects are due to changes in the non-blood cells that help to make blood cells. By understanding how this occurs we may identify better treatments for patients with impaired immune systems.

维生素A缺乏会对人类造成深远的影响，缺乏维生素A会对血细胞造成贫血和无法抵抗感染。我们有证据表明，维生素A缺乏的这些影响是通过维生素A的受体之一发生的。此外，这些影响是由于帮助制造血细胞的非血细胞的变化造成的。通过了解这是如何发生的，我们可能会找到更好的治疗免疫系统受损患者的方法。