BEHAVIORAL PHARMACOLOGY AND TOXICOLOGY

行为药理学项目的主要目的是阐明 （a）谷氨酸介导的 皮质纹状体系统和相关解剖系统，和（B）多巴胺能 系统，包括nigrostraital系统;和功能的影响 兴奋剂和神经安定药。 与这一主要目标相关的是 几个相关目标：1. 为了阐明的功能效果的 “AA 2”或使君子酸兴奋性氨基受体，相对于 兴奋剂的作用，可能具有抗惊厥作用的化合物，以及 酒精戒断; 2. 寻找更有效的AA 2拮抗剂 受体，3. 进行职能相互关系的研究， 多巴胺能和多巴胺能系统在药理学和 解剖术语，和4. 为了研究含硫化合物对CNS的影响， 个氨基酸 这些研究的最终目的是提高我们的 了解精神抑制剂的作用方式， 精神分裂症的功能障碍 第二个目的是提高我们的 了解兴奋剂药物作用和酒精的机制 成瘾;开发具有潜在效用的化合物， 治疗兴奋剂过量、精神分裂症和癫痫;以及 了解皮质纹状体可塑性的可能形式， 系统

The project on Behavioral Pharmacology is primarily aimed at elucidating the interactions between functions of (a) the glutamate-mediated corticostriatal system and related anatomical systems, and (b) dopaminergic systems, including the nigrostraital system; and the functional effects of stimulant and neuroleptic drugs. Related to this primary objective are several related goals: 1. to elucidate of the functional effects of the "AA2" or quisqualic acid excitatory amino receptor, in relation to the effects of stimulants, compounds with possible anticonvulsant effects, and alcohol withdrawal; 2. to search for more effective antagonists of the AA2 receptor, 3. to conduct studies on the functional interrelationships between dopaminergic and glutamatergic systems in pharmacological and anatomical terms, and 4. to investigate CNS effects of sulfur-containing amino acids. The ultimate purpose of these studies is to enhance our understanding of the mode of action of neuroleptics and possibly brain dysfunction in schizophrenia. Secondary purposes are to enhance our understanding of the mechanisms of stimulant drug effects and alcohol addiction; to develop compounds with potential utility for the acute treatment of stimulant overdose, schizophrenia, and seizure disorders; and to understand the possible forms of plasticity in the corticostriatal system.