BRAIN TISSUE TRANSPLANTATION

这项研究主要是针对移植组织， 儿茶酚胺或左旋多巴，包括肾上腺髓质，肿瘤细胞， 基因改变的细胞和胚胎脑组织植入大脑。其 目的是阐明这些组织的性质后， 移植，并阐明宿主脑对移植物的反应。 移植组织具体来说，这些实验使用非灵长类动物 动物模型：（1）发展脑组织移植技术 用于帕金森病的临床应用;（2）开发脑组织 移植技术，使他们最终可能适用于其他 疾病，如精神分裂症和癫痫，如果这些疾病 （3）充分理解并允许此类应用;以及 阐明控制大脑发育和大脑反应的因素 损伤或损害，特别强调黑质纹状体 多巴胺系统在上一个报告年度， 在这些领域取得的。

This study is primarily aimed at transplanting tissues containing catecholamines or L-DOPA, including adrenal medulla, tumor cells, genetically altered cells, and embryonic brain tissue, into the brain. Its purpose is to elucidate the properties of these tissues after transplantation and to elucidate the response of the host brain to the transplanted tissues. Specifically, these experiments employ nonprimate animal models to (1) develop the techniques of brain tissue transplantation for clinical use in Parkinson's disease; (2) develop brain tissue transplantation techniques so they eventually may be applicable to other disorders, such as schizophrenia and epilepsy, if and when these disorders become sufficiently understood to permit such applications; and (3) elucidate factors that control brain development and responses of the brain to injury or impairment, with particular emphasis on the nigrostriatal dopamine system. During the past reporting year, significant progress has been made in these areas.