BEHAVIORAL PHARMACOLOGY AND TOXICOLOGY

行为药理学和毒理学项目的目的是 在阐明神经药理学过程中所涉及的 大脑功能异常和技术的发展 从药理学角度干预脑功能异常 操纵。这些研究涉及异常的诱导 行为和生理状态通过给药 毒品和其他操纵，以及试图改变行为和 通过药物操作的生理状态。特例 感兴趣的主题是已知与 抗精神病药物和药物所致精神病的作用。这些 包括：(I)苯环利定，在人体内可诱导 类似精神分裂症的异常；(Ii)降钙素和 钙通道抑制剂和激活剂正在研究中 因为钙机制之间可能存在的关系 慢性应激所致神经功能的长期变化 抗精神病药；(Iii)癫痫发作和其他与 特别令人感兴趣的是准合格类型的谷氨酸受体 因为谷氨酸突触和 纹状体神经元上的多巴胺突触；(Iv)不同类型 神经系统，特别是兴奋性氨基酸系统 由长期服用抗精神病药物引起的 以便有助于理解 抗精神病药的作用。

The project on behavioral pharmacology and toxicology is aimed at the elucidation of neuropharmacological processes involved in abnormal brain function and at the development of techniques to intervene in abnormal brain function through pharmacological manipulations. These studies involve the induction of abnormal behavioral and physiological states through administration of drugs and other manipulations, and attempts to alter behavior and physiological states by pharmacological manipulations. Particular topics of interest are areas known to be associated with the actions of neuroleptic drugs and drug-induced psychoses. These include (i) phencyclidine, which in humans can induce abnormalities resembling schizophrenia; (ii) calcitonin and calcium-channel inhibitors and activators, are under investigation because of the possible relationships between calcium mechanisms and long-term changes in neuronal function induced by chronic neuroleptics; (iii) seizures and other phenomena related to the quisqualate type of glutamate receptors are of particular interest because of the close association between glutamate synapses and dopamine synapses on striatal neurons; (iv) changes in various neuronal systems particularly excitatory amino acid systems induced by chronic neuroleptic administration are investigated in order to contribute to an understanding of the mechanisms of action of neuroleptics.