CLOZAPINE VS. HALOPERIDOL IN TREATMENT REFRACTORY SCHIZOPHRENIA

氯氮平对比

• 批准号: 3859956
• 负责人: L B BIGELOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3859956
• 关键词: clinical trials; clozapine; dosage; drug adverse effect; extrapyramidal disorder; generalized seizures; haloperidol; human subject; human therapy evaluation; mental disorder chemotherapy; neuropsychological tests; psychopharmacology; schizophrenia

Clozapine has been called an "atypical neuroleptic" because it does not induce the characteristic elevations in prolactin levels nor does it produce the extrapyramidal reactions common to "classical" neuroleptics. We are conducting a blinded crossover study comparing clinical and biological response of treatment refractory schizophrenics to clozapine as compared to haloperidol. When enough patients have been studied we will have clinical, neuropsychological, and SPECT studies of each patient on haloperidol, placebo and clozapine. These results may shed some light on the underlying mechanisms for the often unique clinical responsiveness of patients to clozapine. To date six patients have completed the protocol, an insufficient number to permit data analysis. One patient had a grand mal seizure. This person was noted to have developed a lot of fast activity on her electroencephalogram (EEG) at a low dose of the drug. We are obtaining serial EEG's to see if seizure risk can be predicted.

氯氮平被称为“非典型精神安定药”，因为它不 引起催乳素水平的特征性升高，也不 产生“经典”抗精神病药常见的锥体外系反应。 我们正在进行一项盲法交叉研究，比较临床和 难治性精神分裂症患者对氯氮平的生物反应 与氟哌啶醇相比。 当研究了足够多的患者后，我们将进行临床、 对每位患者进行氟哌啶醇的神经心理学和 SPECT 研究， 安慰剂和氯氮平。 这些结果可能会揭示一些潜在的情况 患者通常具有独特的临床反应的机制 氯氮平。 迄今为止，已有 6 名患者完成了该方案，但数量不足以 允许数据分析。 一名患者出现严重癫痫发作。 此人被注意到有 在她的脑电图 (EEG) 上发现了许多低频率的快速活动 药物的剂量。 我们正在获取连续脑电图，看看癫痫发作风险是否可以 被预测。