ANTI-HIV POTENTIAL OF PENTOSAN POLYSULFATE

戊聚糖多硫酸酯（PPS）是一种半合成的聚阴离子， 作为预防性治疗， 偏头痛和丛集性头痛。 因为我们观察到 治疗患者的循环T细胞，并且由于报告的 另一种硫酸化聚阴离子硫酸葡聚糖与AZT的协同作用， 进行了体外实验，以评估 这种药。 使用人外周血单核细胞，我们已经能够 证明PPS与叠氮杜文（AZT）在抑制 HIV-1增长。 我们还观察到PPS和硫酸葡聚糖单独在 低于1.0 μ g/ml的浓度刺激病毒复制。 后一项发现特别重要，因为据报道， 硫酸葡聚糖的"地下市场" 这表明， 如果他们服用聚阴离子， 例如葡聚糖。 另一方面，发现AZT和PPS之间具有强大的协同作用， 鼓励仔细设计临床研究来评估这一点， 作为艾滋病治疗的辅助药物， 有效降低AZT剂量

Pentosan polysulfate (PPS), a semi-synthetic polyanion, has been under investigation here for a number of years as a prophylactic treatment for migraine and cluster headache. Since we observed an increase of circulating T-cells in treated patients and because of the reported synergism of another sulfated polyanion, dextran sulfate, with AZT, we have performed in-vitro experiments to evaluate the therapeutic potential of this drug. Using human peripheral blood mononuclear cells we have been able to demonstrate synergism of PPS with aziduvine (AZT) in the suppression of HIV-1 growth. We also observed that PPS and dextran sulfate alone in concentrations less than 1.Omug/ml stimulated viral replication. This latter finding is particularly important because of the reported "underground market" for dextran sulfate. It suggests that persons with AIDS could actually worsen their condition if they were to take polyanions such as dextran. On the other hand, the finding of a powerful synergism between AZT and PPS gives encouragement to careful design of clinical research to evaluate this substance as an adjunct to the treatment of AIDS that might permit effective lower dosing of AZT.