THERAPEUTIC AND MECHANISTIC EFFECTS OF SLEEP DEPRIVATION IN DEPRESSION

睡眠剥夺对抑郁症的治疗作用和机制作用

• 批准号: 3859981
• 负责人: R M POST
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3859981
• 关键词: bipolar depression depressed phase; clinical depression; hormone regulation /control mechanism; human subject; metabolism; mood disorders; neurobiology; sleep deprivation; thyrotropin

One night's total sleep deprivation can induce profound antidepressant effects in depressed patients. Following the absence of sleep for one night, 40-60% of depressed patients typically show the transient onset of mood improvement which is then lost following a nap or the next night's recovery sleep. Thus, the sleep deprivation paradigm becomes a non- pharmacological means of acutely inducing altered mood states in a fashion that may yield important information about underlying mechanisms. While the mood changes are usually transient they may, nonetheless, give insights into neural systems involved in mood dysregulation and its acute reversal. Some patients show stable degrees of improvement following sleep deprivations, while others show tolerance and yet others show a relative refractoriness to sleep deprivation-induced mood improvement early in their bipolar depressive episode, but vulnerability to transient or long-lasting switches out of depression later in the course of their episode. These data provide some of the first systematic observations regarding differential neurobiological responsiveness as a function of the course of a bipolar depressive episode. Preliminary data suggest that increases in TSH secretion may be associated with the degree of clinical response to sleep deprivation in our patient population as a whole, as well as individual case studies.

一晚的完全睡眠剥夺会导致严重的抗抑郁 对抑郁症患者的影响 在缺乏睡眠的情况下， 在夜间，40-60%的抑郁症患者通常表现出短暂的发作， 情绪的改善，然后失去后，午睡或第二天晚上的 恢复睡眠 因此，睡眠剥夺范式成为一个非- 以一种方式急性诱导改变情绪状态的药理学手段， 这可能会产生关于潜在机制的重要信息。 而 情绪的变化通常是短暂的，尽管如此， 神经系统参与情绪失调及其急性逆转。 一些患者在睡眠后表现出稳定的改善程度 其他人表现出宽容，而其他人则表现出相对的宽容。 对睡眠剥夺引起的情绪改善的顽固性， 双相抑郁发作，但易受短暂或长期 在发病过程中逐渐摆脱抑郁。 这些 数据提供了一些第一个系统的观察， 不同的神经生物学反应性作为一个功能的过程， 躁郁症发作 初步数据显示， 促甲状腺激素分泌可能与临床反应的程度有关， 睡眠剥夺在我们的病人群体作为一个整体，以及 个案研究。