THERAPEUTIC AND MECHANISTIC EFFECTS OF SLEEP DEPRIVATION IN DEPRESSION

睡眠剥夺对抑郁症的治疗作用和机制作用

• 批准号: 3859981
• 负责人: R M POST
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3859981
• 关键词: bipolar depression depressed phase; clinical depression; hormone regulation /control mechanism; human subject; metabolism; mood disorders; neurobiology; sleep deprivation; thyrotropin

One night's total sleep deprivation can induce profound antidepressant effects in depressed patients. Following the absence of sleep for one night, 40-60% of depressed patients typically show the transient onset of mood improvement which is then lost following a nap or the next night's recovery sleep. Thus, the sleep deprivation paradigm becomes a non- pharmacological means of acutely inducing altered mood states in a fashion that may yield important information about underlying mechanisms. While the mood changes are usually transient they may, nonetheless, give insights into neural systems involved in mood dysregulation and its acute reversal. Some patients show stable degrees of improvement following sleep deprivations, while others show tolerance and yet others show a relative refractoriness to sleep deprivation-induced mood improvement early in their bipolar depressive episode, but vulnerability to transient or long-lasting switches out of depression later in the course of their episode. These data provide some of the first systematic observations regarding differential neurobiological responsiveness as a function of the course of a bipolar depressive episode. Preliminary data suggest that increases in TSH secretion may be associated with the degree of clinical response to sleep deprivation in our patient population as a whole, as well as individual case studies.

一整晚的睡眠剥夺可以产生大量的抗抑郁药物 对抑郁症患者的影响。在一个人没有睡觉之后 夜间，40%-60%的抑郁症患者通常表现出一过性的 情绪改善，然后在午睡或第二天晚上就消失了 恢复睡眠。因此，睡眠剥夺范式成为一种非 以某种方式急性诱导情绪状态改变的药理学手段 这可能会产生关于潜在机制的重要信息。而当 情绪的变化通常是短暂的，尽管如此，它们可能会提供洞察力 与情绪失调及其急性逆转有关的神经系统。 一些患者在睡眠后表现出稳定的改善程度 一些人表现出宽容，另一些人则表现出亲属 对睡眠剥夺诱导的情绪改善早期的难治性 双相抑郁发作，但易受短暂或长期影响 在接下来的一集中，他们会从抑郁中走出来。这些 数据提供了一些关于以下方面的首批系统观察 不同的神经生物学反应作为病程的函数 躁郁症发作。初步数据显示， 促甲状腺激素分泌可能与临床反应程度有关。 睡眠剥夺在我们的患者群体中作为一个整体，以及 个别案例研究。