LONGITUDINAL COURSE OF AFFECTIVE ILLNESS--IMPLICATIONS FOR UNDERLYING MECHANISMS
情感疾病的纵向病程——对潜在机制的影响
基本信息
- 批准号:3859979
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:antidepressants bipolar depression bipolar depression manic phase drug adverse effect environmental stressor human subject hypothyroidism lithium longitudinal human study mental disorder chemotherapy neuroendocrine system neurotransmitters psychological stressor relapse /recurrence social integration stress tricyclic antidepressant
项目摘要
Methods have been developed to systematically assess and plot the
longitudinal course of affective illness in relationship to pharmacological
interventions and psychosocial stressors. We have characterized a course
of illness systematically in this fashion in more than 196 patients with
primary affective disorders. These data re-document the early observations
that the course is often not only one of recurrences, but of progressive
increases in frequency of cycling and severity of illness. Ultra-rapid and
ultradian cycling have also been identified. This cycle acceleration is
occurring in the context of a decreasing incidence of psychosocial
stressors precipitating affective episodes; i.e., as in sensitization and
kindling, they are occurring autonomously. It is against this backdrop
that pharmacological intervention must be considered. We have noted that
one of the previous traditional interventions for bipolar depression,
tricyclic antidepressants, appear to carry a 35% risk of causing definite
or likely switches into mania. In those individuals who show this
induction, we have observed a pattern of increased rapidity of cycling in
the year prior to NIMH admission and longer hospital stays at NIMH,
suggesting that TCA-induced switches are a marker if not the cause of a
more malignant course of illness. A new phenomenon of lithium
discontinuation-induced refractoriness has been described that presents an
additional rationale for continuing patients on long-term maintenance
treatment. We have begun to assess neurobiological correlates of course of
illness using a variety of neurotransmitter and endocrine markers as well
as proteins in the CSF. In patients studied after a prolonged period of
medication-free evaluation, we have observed that rapid cyclers show
significantly higher T4 and free T4 levels compared with non-rapid cyclers.
These data are contrary to previous notions in medicated patients, where
rapid cycling was often associated with hypothyroidism. In bipolar
patients, more lethal suicide attempts appear to occur later in the course
of illness in contrast with unipolar patients reported in the literature
where these often occur after the first episode.
已经开发了系统评估和绘制
情感性疾病的纵向病程与药物治疗的关系
干预和心理社会压力。 我们描述了一个过程
在超过196名患者中,
原发性情感障碍 这些数据重新记录了早期的观测结果
这一过程往往不仅是一个复发,但渐进的
骑自行车的频率和疾病的严重程度增加。 超快速和
超日循环也已被确认。 这种循环加速是
发生在心理社会事件发生率下降的背景下
促使情感发作的紧张性刺激;即,如在敏化和
它们是自发发生的。 正是在这种背景下
必须考虑药物干预。 我们注意到
一种以前治疗双相抑郁症的传统方法,
三环类抗抑郁药,似乎有35%的风险,
或者可能会变成躁狂症 在那些表现出这一点的人身上
诱导,我们已经观察到一种模式,增加循环的速度,
在NIMH入院前一年和在NIMH住院更长时间,
这表明,TCA诱导的开关是一个标志,如果不是原因,
更恶性的病程。 锂的新现象
已经描述了中断引起的不应性,
患者继续接受长期维持治疗的其他依据
治疗 我们已经开始评估神经生物学的相关性,
使用多种神经递质和内分泌标记物的疾病
脑脊液中的蛋白质 在经过长时间研究的患者中,
在无药物评价中,我们观察到快速循环仪显示
与非快速循环者相比,T4和游离T4水平显著较高。
这些数据与先前对药物治疗患者的概念相反,
快速循环常与甲状腺功能减退有关。 以双极
患者,更致命的自杀企图似乎发生在后期的过程中
与文献报道的单极患者相比,
这些通常发生在第一次发作后。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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{{ truncateString('R M POST', 18)}}的其他基金
PSYCHOLOGICAL AND BIOLOGICAL INTERACTIONS IN THE MOOD AND ANXIETY DISORDERS
情绪和焦虑症的心理和生物相互作用
- 批准号:
3900950 - 财政年份:
- 资助金额:
-- - 项目类别:
ANTICONVULSANTS IN LITHIUM-REFRACTORY BIPOLAR PATIENTS
锂难治性双相情感障碍患者的抗惊厥药
- 批准号:
5203736 - 财政年份:
- 资助金额:
-- - 项目类别:
ANTICONVULSANTS IN LITHIUM-REFRACTORY BIPOLAR PATIENTS
锂难治性双相情感障碍患者的抗惊厥药
- 批准号:
3880995 - 财政年份:
- 资助金额:
-- - 项目类别:
THERAPEUTIC AND MECHANISTIC EFFECTS OF SLEEP DEPRIVATION IN DEPRESSION
睡眠剥夺对抑郁症的治疗作用和机制作用
- 批准号:
3880999 - 财政年份:
- 资助金额:
-- - 项目类别:
THERAPEUTIC AND MECHANISTIC EFFECTS OF SLEEP DEPRIVATION IN DEPRESSION
睡眠剥夺对抑郁症的治疗作用和机制作用
- 批准号:
3859981 - 财政年份:
- 资助金额:
-- - 项目类别:
PHENOMENOLOGY, COURSE, & NEUROBIOLOGY OF REFRACTIVE AFFECTIVE DISORDERS
现象学,当然,
- 批准号:
6162957 - 财政年份:
- 资助金额:
-- - 项目类别:
PHARMACOLOGICAL, PHYSIOLOGICAL, BIOCHEMICAL AMYGDALA KINDLING/QUENCHING STUDY
杏仁核药理学、生理学、生物化学点燃/淬灭研究
- 批准号:
6162961 - 财政年份:
- 资助金额:
-- - 项目类别:
NEUROPSYCHOLOGICAL, ANATOMICAL, AND PHYSIOLOGICAL CORRELATES OF MOOD DISORDERS
情绪障碍的神经心理学、解剖学和生理学相关性
- 批准号:
3781430 - 财政年份:
- 资助金额:
-- - 项目类别:
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