THERAPEUTIC AND MECHANISTIC EFFECTS OF SLEEP DEPRIVATION IN DEPRESSION

睡眠剥夺对抑郁症的治疗作用和机制作用

• 批准号: 3880999
• 负责人: R M POST
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3880999
• 关键词: bipolar depression depressed phase; clinical depression; hormone regulation /control mechanism; human therapy evaluation; metabolism; psychotherapy; sleep deprivation; thyrotropin

One night's total sleep deprivation can induce profound antidepressant effects in depressed patients. Following the absence of sleep for one night, 40-60% of depressed patients typically show the transient onset of mood improvement which is then lost following a nap or the next night's recovery sleep. Thus, the sleep deprivation paradigm becomes a non-pharmacological means of acutely inducing altered mood states in a fashion that may yield important information about underlying mechanisms. While the mood changes are usually transient they may, nonetheless, give insights into neural systems involved in mood dysregulation and its acute reversal. Some patients show stable degrees of improvement following sleep deprivations, while others show tolerance and yet others show a relative refractoriness to sleep deprivation-induced mood improvement early in their bipolar depressive episode, but vulnerability to transient or long-lasting switches out of depression later in the course of their episode. These data provide some of the first systematic observations regarding the differential neurobiology as a function of course of depressive episode. Preliminary data suggest that increases in TSH secretion may be associated with degree of clinical response to sleep deprivation in our patient population as a whole, as well as individual case studies. We are planning to utilize O15 blood flow studies to assess regional alterations in metabolism before and after sleep deprivation-induced mood improvement.

一晚的完全睡眠剥夺会导致严重的抗抑郁 对抑郁症患者的影响在缺乏睡眠的情况下， 在夜间，40-60%的抑郁症患者通常表现出短暂的发作， 情绪的改善，然后失去后，午睡或第二天晚上的 恢复睡眠因此，睡眠剥夺模式成为一种 非药物手段，急性诱导改变情绪状态， 可能产生关于潜在机制的重要信息的方式。 虽然情绪的变化通常是短暂的，但它们可能会给 深入了解情绪失调及其急性 逆转一些患者在睡眠后表现出稳定的改善程度 其他人表现出宽容，而其他人则表现出相对的宽容。 对睡眠剥夺引起的情绪改善的顽固性， 双相抑郁发作，但易受短暂或长期 在发病过程中逐渐摆脱抑郁。这些数据 提供了一些第一个系统的观察， 不同的神经生物学作为抑郁发作过程的函数。 初步数据表明，TSH分泌增加可能与 我们的病人对睡眠剥夺的临床反应程度 整体人口，以及个别个案研究。我们计划 利用O 15血流研究来评估 在睡眠剥夺引起的情绪改善之前和之后的新陈代谢。