THERAPEUTIC AND MECHANISTIC EFFECTS OF SLEEP DEPRIVATION IN DEPRESSION

睡眠剥夺对抑郁症的治疗作用和机制作用

• 批准号: 3880999
• 负责人: R M POST
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3880999
• 关键词: bipolar depression depressed phase; clinical depression; hormone regulation /control mechanism; human therapy evaluation; metabolism; psychotherapy; sleep deprivation; thyrotropin

One night's total sleep deprivation can induce profound antidepressant effects in depressed patients. Following the absence of sleep for one night, 40-60% of depressed patients typically show the transient onset of mood improvement which is then lost following a nap or the next night's recovery sleep. Thus, the sleep deprivation paradigm becomes a non-pharmacological means of acutely inducing altered mood states in a fashion that may yield important information about underlying mechanisms. While the mood changes are usually transient they may, nonetheless, give insights into neural systems involved in mood dysregulation and its acute reversal. Some patients show stable degrees of improvement following sleep deprivations, while others show tolerance and yet others show a relative refractoriness to sleep deprivation-induced mood improvement early in their bipolar depressive episode, but vulnerability to transient or long-lasting switches out of depression later in the course of their episode. These data provide some of the first systematic observations regarding the differential neurobiology as a function of course of depressive episode. Preliminary data suggest that increases in TSH secretion may be associated with degree of clinical response to sleep deprivation in our patient population as a whole, as well as individual case studies. We are planning to utilize O15 blood flow studies to assess regional alterations in metabolism before and after sleep deprivation-induced mood improvement.

一晚的完全睡眠剥夺会引起深刻的抗抑郁药 在抑郁症患者中的影响。在没有睡眠之后 晚上，40-60％的抑郁症患者通常显示 情绪改善，然后在午睡或第二天晚上失去 恢复睡眠。因此，睡眠剥夺范式变成了 急性诱导情绪状态的非药理学手段 可能产生有关潜在机制的重要信息的时尚。 尽管情绪变化通常是短暂的，但它们仍然可以给予 对涉及情绪失调及其急性的神经系统的见解 逆转。一些患者在睡眠后显示出稳定的改善程度 剥夺，而其他人则表现出宽容，而其他人则表现出亲戚 耐睡眠剥夺引起的情绪改善的早期 双极性抑郁发作，但易受瞬态或持久的脆弱性 在剧集的过程中，切换出抑郁症。这些数据 提供一些有关 差异神经生物学是抑郁发作的函数。 初步数据表明，TSH分泌的增加可能是相关的 我们患者对睡眠剥夺的临床反应程度 整个人口以及个人案例研究。我们正在计划 利用O15血流研究来评估区域变化 睡眠剥夺引起的情绪改善之前和之后的代谢。