BASIC MECHANISMS OF SEIZURES

癫痫发作的基本机制

• 批准号: 3107692
• 负责人: JAMES A FERRENDELLI
• 金额: $ 69.2万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-01-01 至 1994-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3107692
• 关键词: anticonvulsants; brain disorder chemotherapy; brain electrical activity; butyrolactone; epilepsy

This is a proposal to continue our program project entitled "Basic Mechanisms of Seizures". This application describes a program which represents a major change in direction and emphasis in our research. Recent studies in our laboratories have led to the discovery of a new class of neuroactive chemicals -- alkyl substituted gamma- and thiobutyrolactones. These compounds appear to have novel mechanisms of action by which they can regulate neuronal excitability in brain. We believe that neuroactive butyrolactone and related chemical compounds have great potential diseases and disorders. Because of this we wish to mount a major research effort to learn more about these compounds and their molecular and cellular mechanisms and sites of action. The present program consists of four component projects and an administrative core. The major goals of the component projects are: (1) to study the chemistry of neuroactive butyrolactones and chemically related compounds: (2) to characterize the neurologic effects molecular mechanisms and sites of action of these agents: (3) to define cellular mechanisms of neuroactive butyrolactones and chemically related compounds and characterize some of the mechanisms of inhibitory neurotransmission in mammalian nervous tissue: (4) to define the functional anatomy responsible for the neurologic effects of the above chemicals and for the expression of seizures. Our present program brings together a group of talented and productive medical scientists. Each of the principal investigators has a special find of knowledge and research skills which make him particularly suited to carry out our research goals. They have already demonstrated that they work well together and direct closely interrelated and complementary research projects. Our project should provide substantial information that will improve our knowledge of both normal and abnormal brain function and should lead to a greater understanding and improved treatment of nervous system diseases.

这是一份继续我们名为“BASIC”的项目的建议 癫痫发作的机制“。本申请描述了一个程序，该程序 代表了我们研究方向和重点的重大变化。 我们实验室最近的研究发现了一种新的班级 神经活性物质--烷基取代的伽马--和 硫代丁内酯。这些化合物似乎具有新的作用机制 它们可以调节大脑中神经元的兴奋性的作用。我们 认为神经活性丁内酯和相关化合物有 巨大的潜在疾病和紊乱。正因为如此，我们希望推出一款 主要研究工作以了解更多关于这些化合物及其 分子和细胞机制及作用部位。 本方案由四个组成部分项目和一个 行政核心。组件项目的主要目标是：(1) 神经活性丁内酯类化合物的化学及相关化学研究 化合物：(2)表征神经效应的分子机制 和这些药物的作用部位：(3)定义细胞机制 神经活性丁内酯和化学相关化合物和 描述一些抑制神经传递的机制 哺乳动物神经组织：(4)定义负责的功能解剖学 对于上述化学物质的神经学影响和对 癫痫发作。 我们现在的节目汇聚了一群才华横溢、多产的 医学科学家。每个主要调查人员都有一个特殊的发现 知识和研究技能使他特别适合 实现我们的研究目标。他们已经证明了他们 通力合作，密切联系，相辅相成 研究项目。 我们的项目应该提供大量信息，以改善我们的 对正常和异常大脑功能的了解，并应导致 对神经系统疾病有更好的认识和更好的治疗。