BASIC MECHANISMS OF SEIZURES

这是一项继续研究癫痫基本机制的建议。 本申请描述了一个重新组织的计划项目，该计划项目包括 三个组成部分的研究项目和一个辅助放射自显影核心 项目密切相关，并有一个共同的总体目标 功能解剖特征：正常脑和癫痫脑。 组件项目的主要目标是1)明确角色(S) 哺乳动物小体及其在脑内的联系的病理生理学研究 负责发起、传播和/或终止 全身性惊厥；2)确定实验性的局灶性感觉运动 癫痫发作通过大脑中的局部和长路传播，导致 随着时间的推移兴奋性增加；以及3)生理特征 人脑的感觉、运动、联想和语言皮质 目的为提高癫痫的外科治疗水平，开发更多的 在人脑中定位癫痫灶的综合方法，并 确定癫痫手术治疗对局部癫痫的影响 与癫痫灶相关的代谢异常。放射自显影 CORE将维护和开发定量图像分析技术 放射自显影实验和开发新的放射性示踪剂， 用于研究的数学模型和定量放射自显影方法 癫痫发作。 该计划汇集了几个优秀和多产的基础和 在解剖学领域有技能和兴趣的临床科学家， 生物化学、生理学、药理学、放射学、神经学和 神经外科手术。我们的研究应该会提供极大的改进 对正常脑的认识及两者的病理生理机制 实验性和临床性癫痫发作。这一信息最终将 提高癫痫患者的诊断和治疗水平。

This is a proposal to continue our studies of basic mechanism of seizures. This application describes a re-organized program project consisting of three component research projects and a support autoradiography core project which are closely inter-related and have a common overall goal to characterize functional anatomy normal and epileptic brain. The major objectives of the component projects are 1) to define the role(s) of the mammillary bodies and their connections in brain in pathophysiologic processes responsible for initiation, propogation and/or termination of generalized seizures; 2) to determine how experimental focal sensorimotor seizures travel through local and long circuits in brain causing an increase in excitability over time; and 3) to physiologically characterize sensory, motor, associative and language cortex in human brain for the purpose of improving surgical treatment of epilepsy, to develop more comprehensive methods for localizing seizure foci in human brain, and to determine the effect of surgical treatment of epilepsy on regional metabolic abnormalities associated with seizure foci. The autoradiography core will maintain and develop quantitative image analysis techniques for autoradiographic experiments and develop new radioactive tracers, mathematical models and quantitative autoradiographic methods for studying seizures. The program brings together several excellent and productive basic and clinical scientists with skills and interests in the fields of anatomy, biochemistry, physiology, pharmacology, radiology, neurology and neurological surgery. Our research should provide greatly improved understanding of normal brain and pathophysiological mechanisms of both experimental and clinical seizures. This information will eventually improve diagnosis and treatment of the patient with epilepsy.