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EpiStressNet: A biosocial systems approach to understanding the epigenetic embedding of social stress responses.

EpiStressNet：一种理解社会压力反应的表观遗传嵌入的生物社会系统方法。

基本信息

批准号：
ES/N000528/1
负责人：
Vincent Cunliffe
金额：
$ 25.54万
依托单位：
University of Sheffield
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=ES%2FN000528%2F1
关键词：
EpiStressNet biosocial systems approach understanding

项目摘要

The social environments in which we live provide daily challenges that affect how we think and feel, influencing our behaviour and sense of well-being. However, it is far from clear exactly how these experiences affect us at a physical level. Recent research in biology has discovered molecules that are found in all of our cells, which interpret our experiences by switching genes on or off in particular cell types. These molecules, or "epigenetic" mechanisms, bind to DNA and control gene activity, which in turn change the functions of our cells, tissues and organs, and so affect what we think, feel and do. We are beginning to understand that these epigenetic mechanisms are modified by factors that also affect our health, and recent evidence indicates that social stress is one such factor. Societies in which there is a bigger gap between rich and poor, such as the UK, also have bigger, more stressful social and health inequalities. Good evidence suggests that the social stress caused by social inequality leads to ill-health and that this link may involve epigenetic mechanisms. This project aims to build a network of biological and social scientists to explore how social stress causes epigenetic changes which affect biology and behaviour. To address this problem, we will establish a team with wide-ranging expertise in investigating (a) the physical effects of stress on gene activity in the brain and the body, (b) the impacts of social inequality on health, and (c) how we think about the way our experiences get under our skin to shape behaviour and well-being. This team of social science, public health and biology researchers, will develop and carry out novel shared projects. We will hold discussion meetings to consider new biological and sociological ideas together, and share new discoveries that will help to explain how social stresses exert their effects on the brain and the rest of the body, and the roles of epigenetics in these processes. We will also meet with industrial, government and health service professionals, to consider the potential impacts of our research for their work, and engage with the general public more broadly to discuss the wider implications of this research for society.

我们生活的社会环境提供了日常挑战，影响我们的思维和感受，影响我们的行为和幸福感。然而，我们还不清楚这些经历在物理层面上对我们的影响。最近的生物学研究发现了在我们所有细胞中发现的分子，这些分子通过在特定细胞类型中打开或关闭基因来解释我们的经历。这些分子，或“表观遗传”机制，与DNA结合并控制基因活性，从而改变我们细胞，组织和器官的功能，从而影响我们的想法，感觉和行为。我们开始了解到，这些表观遗传机制受到影响我们健康的因素的影响，最近的证据表明，社会压力就是这样一个因素。贫富差距更大的社会，如英国，也有更大，更有压力的社会和健康不平等。有充分的证据表明，社会不平等造成的社会压力导致健康不良，这种联系可能涉及表观遗传机制。该项目旨在建立一个生物和社会科学家网络，探索社会压力如何导致影响生物和行为的表观遗传变化。为了解决这个问题，我们将建立一个拥有广泛专业知识的团队，调查（a）压力对大脑和身体基因活动的物理影响，（B）社会不平等对健康的影响，以及（c）我们如何看待我们的经历如何影响我们的行为和福祉。这支由社会科学、公共卫生和生物学研究人员组成的团队将开发和开展新颖的共享项目。我们将举行讨论会，共同考虑新的生物学和社会学思想，并分享新的发现，这将有助于解释社会压力如何对大脑和身体的其他部分产生影响，以及表观遗传学在这些过程中的作用。我们还将会见工业，政府和卫生服务专业人士，考虑我们的研究对他们的工作的潜在影响，并与公众更广泛地讨论这项研究对社会的更广泛的影响。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae

斑马鱼幼虫缺氧诱导因子和糖皮质激素信号之间的双向串扰

DOI：
10.1101/748566
发表时间：
2019
期刊：
影响因子：
0
作者：
Marchi D
通讯作者：
Marchi D

Genetic Disruption of 21-Hydroxylase in Zebrafish Causes Interrenal Hyperplasia.

DOI：
10.1210/en.2017-00549
发表时间：
2017-12-01
期刊：
Endocrinology
影响因子：
4.8
作者：
Eachus H;Zaucker A;Oakes JA;Griffin A;Weger M;Güran T;Taylor A;Harris A;Greenfield A;Quanson JL;Storbeck KH;Cunliffe VT;Müller F;Krone N
通讯作者：
Krone N

Epigenetics and primary care.

表观遗传学和初级保健。