NATURAL HISTORY OF HIV INFECTION IN INFANTS OF ADDICTED MOTHERS

成瘾母亲的婴儿感染艾滋病毒的自然史

• 批准号: 3863983
• 负责人: KEITH KRASINSKI
• 金额: --
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3863983
• 关键词: AIDS; HIV infections; cellular immunity; clinical trials; communicable disease transmission; congenital infection; drug addiction; human immunodeficiency virus; human subject; humoral immunity; infant human (0-1 year); mother child interaction; pediatric AIDS; prognosis

This study will (1) measure cell-mediated and humoral immunity in drug-addicted mothers and their infants in order to define immunologic aberrations as a result of drug use versus infection with HIV; (2) determine the vertical transmission rate of HIV infection and the time at which transmission occurs; (3) define maternal characteristics that most frequently result in HIV transmission to infants; and (4) identify prognostic indicators of HIV infection in children.

本研究将(1)检测细胞免疫和体液免疫。 吸毒母亲和她们的婴儿，以确定免疫学 与艾滋病毒感染相比，吸毒导致的畸形；(2) 确定艾滋病毒感染的垂直传播率和 发生哪种传播；(3)定义母体特征 经常导致艾滋病毒传播给婴儿；和(4)确定 儿童感染艾滋病毒的预后指标。