HIV-INFECTED CHILDREN--IV GAMMAGLOBULIN THERAPY AND BACTERIAL INFECTION

HIV感染儿童--IV丙种球蛋白治疗和细菌感染

• 批准号: 3904498
• 负责人: KEITH KRASINSKI
• 金额: --
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3904498
• 关键词: antiAIDS agent; bacterial disease; child (0-11); clinical trials; drug administration routes; gamma globulin; human immunodeficiency virus 1; human therapy evaluation; injection /infusion; secondary infection

This study will determine if a monthly intravenous immunoglobulin administration, compared to intravenous placebo, will significantly reduce the rate of serious, life-threatening bacterial infections in HIV- infected children, if it will reduce the rate of viral, opportunistic and minor infections, days of hospitalization, days of antibiotic use and progression of HIV disease.

这项研究将确定每月静脉注射免疫球蛋白 与静脉注射安慰剂相比，给药将显著 降低艾滋病毒中严重的、危及生命的细菌感染率- 受感染的儿童，如果它能降低病毒、机会主义和 轻微感染，住院天数，抗生素使用天数和 艾滋病毒疾病的进展。