THE SINGLE-DOSE PHARMACOKINETICS OF HUMAN MENOPAUSAL GONADOTROPINS

人类绝经期促性腺激素的单剂量药代动力学

• 批准号: 3864060
• 负责人: STEVEN T NAKAJIMA
• 金额: --
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3864060
• 关键词: clinical trials; dosage; drug metabolism; female; gonadotropin releasing factor; gonadotropins; hormone metabolism; human subject; menopause; sex hormone analog

This study seeks to clarify the single-dose pharmacokinetics of human menopausal gonadotropin in women, after a pretreatment period of leuprolide acetate, a long-acting analogue of gonadotropin releasing hormone. This study design will characterize gonadotropin levels after a single dose of hMG, without the conflicting background production of endogenous gonadotropins by the pituitary gland.

本研究旨在阐明人体单剂量的药代动力学 亮丙瑞林预处理期后女性的绝经期促性腺激素 醋酸盐，促性腺激素释放激素的长效类似物。这 研究设计将描述单次给药后促性腺激素水平 hMG，没有内源性的冲突背景产生， 促性腺激素。