CORTICOTROPIN RELEASING FACTOR AND SUPPRESSION OF HUMAN IMMUNE FUNCTION

促肾上腺皮质激素释放因子与人体免疫功能的抑制

• 批准号: 3863981
• 负责人: CHARLES S HOLLANDER
• 金额: --
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3863981
• 关键词: adrenal disorder; clinical trials; corticotropin releasing factor; dexamethasone; human subject; immunosuppressive; psychoneuroimmunology; steroid hormone

The overall objective of this study is to investigate the role of CRF in the pathophysiology of neuroimmunomodulation. More specifically, the protocol will determine the effect of exogenous administration of CRF on immune parameters in the following subjects: (1) normal subjects both before and after their HPA axis is inhibited by dexamethasone, (2) subjects with primary adrenal insufficiency on physiological steroid replacement, and (3) ACTH-deficient patients.

本研究的总体目标是研究CRF在以下方面的作用： 神经免疫调节的病理生理学。更具体而言是 方案将确定CRF外源性给药对 以下受试者的免疫参数：（1）正常受试者， 地塞米松抑制HPA轴前后，（2）受试者 用生理性类固醇替代治疗原发性肾上腺功能不全， （3）ACTH缺乏患者。