Defining the mechanisms of action for ozonide antimalarials

确定臭氧化物抗疟药的作用机制

• 批准号: nhmrc : GNT1128003
• 负责人: Dr Darren Creek
• 金额: $ 66.82万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-mechanisms-action-ozonide-antimalarials/1347658
• 关键词: Defining; mechanisms; action; ozonide; antimalarials

Deadly malaria parasites have emerged that are resistant to all classes of approved drugs. Ozonides are a new class of medicines recently approved for malaria, and provide a much-needed treatment option for multi-drug resistant infections. However, the mode of action and potential for cross-resistance is poorly understood. This project will use modern analytical techniques to measure the impact of ozonides on parasite biochemistry to reveal mechanisms involved in drug action and resistance.

致命的疟疾寄生虫已经出现，对所有类别的批准药物都有抗药性。Ozonides是最近批准用于疟疾的一类新药，为耐多药感染提供了急需的治疗选择。然而，对交叉耐药性的作用方式和可能性知之甚少。该项目将使用现代分析技术来测量臭氧化物对寄生虫生物化学的影响，以揭示药物作用和抗药性的机制。