Discovery of active metabolic pathways suitable for drug targeting in Trypanosoma brucei

发现适合布氏锥虫药物靶向的活性代谢途径

• 批准号: nhmrc : 1087735
• 负责人: Dr Darren Creek
• 金额: $ 32.37万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/discovery-active-metabolic-trypanosoma-brucei/519183
• 关键词: Discovery; active; metabolic; pathways; suitable

Sleeping Sickness is a parasitic disease affecting many of the world’s poorest countries, and is fatal if left untreated. The aim of this project is to identify new metabolic pathways in the parasite that causes Sleeping Sickness, and to investigate how drugs interfere with parasite metabolism. This will provide the basis for new drug discovery efforts and facilitate the development of new medicines for Sleeping Sickness.

昏睡病是一种寄生虫病，影响着世界上许多最贫穷的国家，如果不及时治疗是致命的。该项目的目的是确定导致昏睡病的寄生虫的新代谢途径，并研究药物如何干扰寄生虫代谢。这将为新药发现工作提供基础，并促进昏睡病新药的开发。