COMPUTER FACILITY FOR RAPID 3-D IMAGING

用于快速 3D 成像的计算机设备

• 批准号: 3521218
• 负责人: JOHN W WEISEL
• 金额: $ 20.2万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-18 至 1993-10-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3521218
• 关键词: biomedical equipment purchase; computed axial tomography; computer center; fluorescence microscopy; image enhancement; imaging /visualization /scanning; magnetic resonance imaging; microscopy

Much research on complex biological systems at all levels of structure shares the need for rapid calculation of three dimensional structures and their visualization and manipulation in real time. Structural data at the molecular and cellular levels of the core user group are derived primarily from electron microscopy, while images of living cells are obtained by fluorescent light microscopy; data at the organ and tissue level are derived from living people by the techniques of computed tomography (CT) and magnetic resonance imaging (MRI). The VAXserver 3900, X-windows terminals as well as the Stardent supergraphics computer with enhancements are needed by all users of the facility for computation and visualization of data. The Optronics interface is needed for digitizing data on the existing Optronics microdensitometer. The fluorescent light microscope workstation and CCD and SIT cameras and are necessary for collecting data from living cells. The core user group consists of 14 scientists from six different departments or institutes pursuing ten research projects. The subjects studied by the major users are diverse: muscle thick filament structure, including the backbone and crossbridge interactions, dynamics of development and other changes in muscle and non-muscle cells, excitation-contraction coupling, structure and function of retinal circuitry, role of oncogenes in growth and differentiation, alveolar fluid uptake, fibrinogen and fibrin structure and assembly, and imaging of anatomical structures by CT and MRI. Most of the core users have some experience with computer image processing and graphics applied to biological problems and have research programs that have been limited by the currently available instrumentation. The requested equipment will open exciting new research possibilities for a wide variety of scientists at the University of Pennsylvania.

关于各个级别的复杂生物系统的大量研究 分享需要快速计算三维结构的需求 以及他们实时的可视化和操纵。 结构数据 在核心用户组的分子和细胞水平上得出 主要来自电子显微镜，而活细胞的图像是 通过荧光光学显微镜获得；器官和组织的数据 水平是通过计算的技术源自活人的 断层扫描（CT）和磁共振成像（MRI）。 VaxServer 3900，X-Windows终端以及Stardent Supergraphics计算机 设施的所有用户都需要增强功能 数据的计算和可视化。 optronics接口是 对现有的Optronics微敏度计的数据数字化所需。 荧光灯显微镜工作站和CCD和坐着相机以及 对于从活细胞收集数据是必要的。 核心用户 小组由来自六个不同部门的14位科学家组成或 从事十个研究项目的机构。 由 主要用户是多样的：肌肉厚细丝结构，包括 骨干和Crossbridge的相互作用，开发动力和其他 肌肉和非肌肉细胞的变化，激发反应耦合， 视网膜电路的结构和功能，癌基因在生长中的作用 和分化，肺泡液吸收，纤维蛋白原和纤维蛋白 结构和组装，以及通过CT和CT对解剖结构进行成像 MRI。 大多数核心用户都有计算机图像的经验 处理和图形应用于生物学问题并进行研究 被当前可用的程序限制 仪器。 请求的设备将开放令人兴奋的新 为各种科学家的研究可能性 宾夕法尼亚大学。