Defining the requirement for the inhibition of Bak to the pathogenesis of cytomegalovirus infection

确定 Bak 抑制对巨细胞病毒感染发病机制的要求

• 批准号: nhmrc : 634480
• 负责人: Dr Christopher Andoniou
• 金额: $ 39.52万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-requirement-inhibition-cytomegalovirus-infection/83130
• 关键词: Defining; requirement; inhibition; Bak; pathogenesis

Apoptosis, or programmed cell death is a powerful defence mechanism against viral infection. Thus, to replicate efficiently viruses have evolved means to inhibit apoptosis. The central aim of this work is to understand how cytomegalovirus prevents cell death protein during infection. The proposed studies will improve our understanding of the mechanisms that regulate viral replication and will contribute insights into the normal processes that control cell survival.

细胞凋亡或程序性细胞死亡是一种对抗病毒感染的强大防御机制。因此，为了有效地复制，病毒进化出了抑制细胞凋亡的手段。这项工作的中心目的是了解巨细胞病毒如何在感染期间阻止细胞死亡蛋白。拟议的研究将提高我们对调节病毒复制机制的理解，并将有助于了解控制细胞存活的正常过程。