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Mechanisms of virally-induced immunosuppression: effects on DC-NK networks

Mechanisms of virally-induced immunosuppression: effects on DC-NK networks
病毒诱导的免疫抑制机制：对 DC-NK 网络的影响
批准号：
nhmrc : 572641
负责人：
Dr Christopher Andoniou
金额：
$37.76万
依托单位：
The University of Western Australia
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2009
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2009-01-01 至 2011-12-31
来源：
https://researchdata.edu.au/mechanisms-virally-induced-nk-networks/76187
关键词：
Mechanismsvirallyinducedimmunosuppressioneffects

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英文摘要
Cytomegalovirus (CMV) infection induces immunosuppression that often results in adverse clinical outcomes. Our previous work established that dendritic cells (DC), cells involved in the initiation of immune responses, are a principle target for CMV. This proposal will test the hypothesis that CMV-induced immunosuppression is mediated by viral interference with DC. Understanding the mechanisms involved in the induction of immunosuppression is a crucial step towards developing better therapies.
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