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The interplay between IL-6 and GVHD on anti-viral and anti-leukaemic immunity

The interplay between IL-6 and GVHD on anti-viral and anti-leukaemic immunity
IL-6和GVHD在抗病毒和抗白血病免疫中的相互作用
批准号：
nhmrc : GNT1109288
负责人：
Dr Christopher Andoniou
金额：
$48.94万
依托单位：
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2016
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2016-01-01 至 --
来源：
https://researchdata.edu.au/interplay-il-6-leukaemic-immunity/1346680
关键词：
interplaybetweenILGVHDanti

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中文摘要
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英文摘要
Bone marrow transplantation can cure leukaemia but infection, graft-versus-host disease (GVHD) and leukaemia relapse remain challenging problems. We recently completed an early phase clinical study on GVHD prevention using interleukin-6 blockade. Interestingly, the rate of virus reactivation was also lower. This project will use a newly developed mouse model and stored clinical samples to understand the underlying mechanism and whether it also has an impact on anti-leukaemic immunity.
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Effective therapies to treat viral infections and their complications in transplantation
  • 批准号：
    nhmrc : GNT1125357
  • 项目类别：
    Project Grants
  • 资助金额：
    $110.05万
  • 财政年份：
    2017
  • 负责人：
    Dr Christopher Andoniou
  • 依托单位：
    Monash University
Effective therapies to treat viral infections and their complications in transplantation
  • 批准号：
    nhmrc : 1125357
  • 项目类别：
    Project Grants
  • 资助金额：
    $75.19万
  • 财政年份：
    2017
  • 负责人：
    Dr Christopher Andoniou
  • 依托单位：
    The University of Western Australia
The interplay between IL-6 and GVHD on anti-viral and anti-leukaemic immunity
  • 批准号：
    nhmrc : 1109288
  • 项目类别：
    Project Grants
  • 资助金额：
    $33.54万
  • 财政年份：
    2016
  • 负责人：
    Dr Christopher Andoniou
  • 依托单位：
    Queensland Institute of Medical Research
Using viral inhibitors to understand the regualtion of apoptosis
  • 批准号：
    DP150102437
  • 项目类别：
    Discovery Projects
  • 资助金额：
    $17.35万
  • 财政年份：
    2015
  • 负责人：
    Dr Christopher Andoniou
  • 依托单位：
    The University of Western Australia
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