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BIOLOGICAL PROPERTIES OF GOSSYPOL AND DERIVATIVES

BIOLOGICAL PROPERTIES OF GOSSYPOL AND DERIVATIVES
棉酚及其衍生物的生物特性
批准号：
3877462
负责人：
DAVID L VANDER JAGT
金额：
$0.0万
依托单位：
UNIVERSITY OF NEW MEXICO
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3877462
关键词：
Plasmodium falciparum aldehyde reductase antimalarial agents antiprotozoal agents antiviral agents bioenergetics chemical structure function drug adverse effect drug design /synthesis /production enzyme inhibitors gestational diabetes mellitus herpes simplex virus 2 lactate dehydrogenases liver metabolism parasitic disease chemotherapy spermatogenesis inhibitor transferase trypanosomiasis

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中文摘要
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英文摘要
Derivatives of the disesquiterpene gossypol will be synthesized. This primarily involves modification of the aldehyde functional groups of gossypol. Gossypol and derivatives will be evaluated in three different biological assay systems. 1. Gossypol and derivatives will be evaluated for their antiparasitic activity against the malarial parasite P.falciparum. Activity will be compared with the ability of the drugs to inhibit parasite lactate dehydrogenase, the putative target. 2. Gossypol and derivatives will be evaluated for their antiviral properties against herpes simplex type II. 3. Gossypol and derivatives will be evaluated for their properties as inhibitors of aldose reductase from human placenta. This enzyme is the target for drugs which may be useful in the treatment of diabetic complications.
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Oxidative Stress, VEGF and Retinopathy
  • 批准号：
    6620288
  • 项目类别：
  • 资助金额：
    $15.0万
  • 财政年份：
    2002
  • 负责人：
    DAVID L VANDER JAGT
  • 依托单位：
    UNIVERSITY OF NEW MEXICO
Oxidative Stress, VEGF and Retinopathy
  • 批准号：
    6745536
  • 项目类别：
  • 资助金额：
    $15.0万
  • 财政年份：
    2002
  • 负责人：
    DAVID L VANDER JAGT
  • 依托单位：
    UNIVERSITY OF NEW MEXICO
Oxidative Stress, VEGF and Retinopathy
  • 批准号：
    6414754
  • 项目类别：
  • 资助金额：
    $15.0万
  • 财政年份：
    2002
  • 负责人：
    DAVID L VANDER JAGT
  • 依托单位：
    UNIVERSITY OF NEW MEXICO
HUMAN ALDOSE REDUCTASE AND DIABETIC COMPLICATIONS
  • 批准号：
    3244584
  • 项目类别：
  • 资助金额：
    $11.53万
  • 财政年份：
    1992
  • 负责人：
    DAVID L VANDER JAGT
  • 依托单位：
    UNIVERSITY OF NEW MEXICO
海外基金