PATHOPHYSIOLOGY OF THE PULMONARY CIRCULATION

构成这项申请的六个项目涉及到相互关联的 健康和疾病中的肺循环方面。项目1 考虑血液从右心室流到 左心房，并建议解开有机体 用来重新调整肺血管的阻抗特性 疾病，以最大限度地减少心脏工作。接下来的两个项目涉及 肺血管床对异常气体张力的反应。更多 特别是，项目2研究了低氧反应的发展 在胚胎生命和开始的时间之间的关系 反射和其他调节机制，而项目3旨在 阐明生物体的一般条件的影响(例如， 缺氧、酸碱失衡)对局部异常气体的反应 组成。项目4进一步推进了这项研究，解决了 血管平滑肌本身的生理学及其影响因素 它的收缩。在项目5中，我们建议确定 血管系统的各种特征，因为它们影响主要的 肺功能，气体交换。最后，项目6集中在 损伤对肺内皮细胞的影响，并提供了一个解剖学基础 为一些功能研究奠定了基础。

The six projects constituting this application deal with interrelated aspects of the pulmonary circulation in health and disease. Project 1 considers the mechanical problem of blood flow from the right ventricle to the left atrium, and proposes to unravel the mechanisms which the organism uses to readjust the impedance characteristics of the lung vasculature in disease, to minimize cardiac work. The next two projects deal with response of the lung vascular bed to abnormal gas tensions. More particularly, Project 2 studies the development of the hypoxic response during embryonic life and the time relationship between inception of that reflex and other regulating mechanisms, while Project 3 is designed to elucidate the influence of the general conditions of the organism (e.g., hypoxia, acid-base imbalance) on the local response to abnormal gas composition. Project 4 carries this study one step further by addressing itself to the physiology of vascular smooth muscle and factors affecting its contraction. In Project 5, we propose to determine the effects of various characteristics of the vascular system as they affect the main function of the lung, gas exchange. Finally, Project 6 concentrates on the effects of injury on the pulmonary endothelium, and provides an anatomical basis for some of the functional studies.