PATHOPHYSIOLOGY OF THE PULMONARY CIRCULATION

肺循环的病理生理学

• 批准号: 3098393
• 负责人: LEON E FARHI
• 金额: $ 63.74万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-12-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3098393
• 关键词: embolism; pulmonary circulation; pulmonary circulation obstruction

The six projects constituting this application deal with interrelated aspects of the pulmonary circulation in health and disease. Project 1 considers the mechanical problem of blood flow from the right ventricle to the left atrium, and proposes to unravel the mechanisms which the organism uses to readjust the impedance characteristics of the lung vasculature in disease, to minimize cardiac work. The next two projects deal with response of the lung vascular bed to abnormal gas tensions. More particularly, Project 2 studies the development of the hypoxic response during embryonic life and the time relationship between inception of that reflex and other regulating mechanisms, while Project 3 is designed to elucidate the influence of the general conditions of the organism (e.g., hypoxia, acid-base imbalance) on the local response to abnormal gas composition. Project 4 carries this study one step further by addressing itself to the physiology of vascular smooth muscle and factors affecting its contraction. In Project 5, we propose to determine the effects of various characteristics of the vascular system as they affect the main function of the lung, gas exchange. Finally, Project 6 concentrates on the effects of injury on the pulmonary endothelium, and provides an anatomical basis for some of the functional studies.

构成本申请的六个项目涉及相互关联的

项目成果

High-frequency oscillation during simulated altitude exposure.

模拟高空暴露期间的高频振荡。

• DOI: 10.1097/00003246-199011000-00015
• 发表时间: 1990
• 期刊: Critical care medicine
• 影响因子: 8.8
• 作者: Saltzman,AR;Klocke,RA;AckermanJr,NB;Land,P;Grant,BJ;Aquilina,AT
• 通讯作者: Aquilina,AT

Role of molecular diffusion in conventional and high frequency ventilation.

分子扩散在常规和高频通气中的作用。

• DOI: 10.1164/ajrccm/142.4.802
• 发表时间: 1990
• 期刊: The American review of respiratory disease
• 作者: Klocke,RA;Saltzman,AR;Grant,BJ;Aquilina,AT;Zhang,S
• 通讯作者: Zhang,S

Signal transduction in endothelin-induced contraction of rabbit pulmonary vein.

内皮素诱导的兔肺静脉收缩的信号转导。

• DOI: 10.1016/0952-0600(90)90002-z
• 发表时间: 1990
• 期刊: Pulmonary pharmacology
• 作者: Steffan,M;Russell,JA
• 通讯作者: Russell,JA

Pulmonary hypoxic vasoconstriction: how strong? How fast?

肺缺氧血管收缩：有多强？

• DOI: 10.1016/0034-5687(92)90017-q
• 发表时间: 1992
• 期刊: Respiration physiology
• 作者: Sheehan,DW;Klocke,RA;Farhi,LE
• 通讯作者: Farhi,LE

Prolonged lobar hypoxia in vivo enhances the responsivity of isolated pulmonary veins to hypoxia.

• DOI: 10.1164/ajrccm/145.3.640
• 发表时间: 1992-03
• 期刊: The American review of respiratory disease
• 作者: D. Sheehan;L. Farhi;J. Russell