AN INVESTIGATION OF PRIMARY DEPRESSIVES WITH SECONDARY ALCOHOLISM

对继发性酗酒的原发性抑郁症患者的调查

• 批准号: 3880991
• 负责人: E LEIBENLUFT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3880991
• 关键词: alcoholism /alcohol abuse; clinical depression; neurochemistry; questionnaires; seasonal affective disorder; sign /symptom

Both clinicians and patients frequently claim that depressed patients "self-medicate" their depression with alcohol, and primary depression with secondary alcoholism probably accounts for 5-10% of the alcoholic population. While self-medication alone is clearly not a sufficient explanation for psychiatric patients' addictions, the self-medication hypothesis has important implications for patient care and for our understanding of the pathophysiology of mood disorders. For example, a patient's choice of psychoactive substance may provide a clue to the neurochemistry underlying his symptoms. We are conducting a pilot study designed to elucidate the characteristics of primary depressives who claim to self-medicate with alcohol. Our index group consists of patients who meet DSM-III-R criteria for major depressive disorder (MDD), and for alcohol dependence (AD). We compare them to two other clinical groups on a number of clinical and phenomenological measures. The two comparison groups consist of patients with NMD but no history of alcohol abuse or AD; and patients with a history of AD who have never had MDD. In conjunction with the above project, we have developed a questionnaire that asks about patients' use of alcohol, carbohydrates, and caffeine in response to specific depressive symptoms. We gave the questionnaire to a sample of patients with seasonal affective disorder (SAD). The SAD patients reported using each of the three substances in response to a specific profile of symptoms, and reported that each substance had a distinctive effect on their symptoms. We are currently administering the questionnaire to a sample of patients with MDD and AD.

临床医生和患者都经常声称抑郁症患者 用酒精“自我治疗”他们的抑郁症，用酒精治疗原发性抑郁症 继发性酒精中毒可能占酗酒者的5%-10% 人口。虽然仅靠自我用药显然不足以 精神病人成瘾、自我用药释疑 假设对病人护理和我们的 对心境障碍的病理生理学的理解。例如，一个 患者对精神活性物质的选择可能为 他的症状背后的神经化学。 我们正在进行一项初步研究，旨在阐明这些特征 自称用酒精进行自我治疗的抑郁症患者。我们的指数 小组由符合DSM-III-R标准的重度抑郁症患者组成 精神障碍(MDD)和酒精依赖(AD)。我们把它们比作两个 其他临床小组关于一些临床和现象学的 措施。两个对照组由NMD患者组成，但没有 有酗酒或阿尔茨海默病病史；有AD病史的患者 从未患过MDD。 结合上述项目，我们编制了一份调查问卷 询问患者对酒精、碳水化合物和咖啡因的使用情况 对特定抑郁症状的反应。我们把调查问卷交给了一位 季节性情感障碍(SAD)患者样本。SAD患者 报告使用这三种物质中的每一种来回应特定的 症状概况，并报告每种物质都有独特的 对他们的症状有影响。我们目前正在管理调查问卷 给MDD和AD患者的样本。