AN INVESTIGATION OF PRIMARY DEPRESSIVES WITH SECONDARY ALCOHOLISM
AN INVESTIGATION OF PRIMARY DEPRESSIVES WITH SECONDARY ALCOHOLISM
批准号:
3859973
负责人:
E LEIBENLUFT
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
酒精依赖与重大精神疾病的共病,
包括情感障碍在内的疾病,正受到越来越多的关注
精神病学文献。然而,很少有系统的研究做过。
对原发性抑郁症和继发性酒精中毒患者的影响。这些
患者,他们通常声称自己用药来治疗他们的抑郁症
酒精,是很有趣的研究,因为他们选择的精神活性
物质可能为其背后的神经化学提供线索
症状。在此期间,我们完成了一项初步研究,将
合并有原发性抑郁症和继发性抑郁症病史的患者
两个对照组的酒精依赖:有酒精依赖病史的患者
抑郁症,但没有酗酒或依赖史,以及患有
有酒精依赖史,但没有情感性疾病。患者被
根据年龄、性别和全球功能评估得分进行匹配。
每组11名患者完成了标准化检查,在检查中我们
有特征的症状、家族史和吸毒和酗酒的模式
虐待。结果表明,合并的患者明显更多
比抑郁症患者更有可能达到DSM-III-R的恐慌标准
精神障碍(p=0.04)。与抑郁症患者相比,患有抑郁症的患者
明显更高的轻躁狂得分(p=0.03),尽管(除
指一个并发的病人)既不是抑郁的病人,也不是合并的病人
符合双相情感障碍的标准。特别是,合并有
原发性抑郁症和继发性酒精中毒可能倾向于“三重病态”,
有抑郁、焦虑和酗酒的症状。此外,
共病患者所经历的焦虑和易怒的增加可能
导致他们酗酒的倾向。
结合上述项目,我们制定了一份调查问卷,以
研究患者对酒精、碳水化合物和咖啡因的使用情况
特定的抑郁症状。调查问卷已经发放给了
季节性情感障碍、非季节性情感障碍患者,
原发性抑郁症伴继发性酒精依赖,酒精依赖
没有情感障碍,也没有正常人。数据目前正在
分析以建立重测信度,并确定差异
在这些物质的使用上,这两组人之间存在差异。
英文摘要
The comorbidity of alcohol dependence with major psychiatric illness,
including affective disorders, is receiving increased attention in the
psychiatric literature. However, little systematic research has been done
on patients with primary depression and secondary alcoholism. These
patients, who typically claim to "self-medicate" their depression with
alcohol, are interesting to study because their choice of psychoactive
substance may provide a clue to the neurochemistry underlying their
symptoms. During this period, we completed a pilot study comparing
patients with a history of comorbid primary depression and secondary
alcohol dependence to two comparison groups: patients with a history of
depression but no history of alcohol abuse or dependence, and patients with
a history of alcohol dependence but no affective illness. Patients were
matched according to age, sex, and Global Assessment of Functioning score.
Eleven patients in each group completed a standardized work-up in which we
characterized symptoms, family history, and pattern of drug and alcohol
abuse. Results indicate that comorbid patients are significantly more
likely than depressed patients to meet DSM-III-R criteria for panic
disorder (p=0.04). Compared to depressed patients, comorbid patients have
significantly higher hypomania scores (p=0.03) although (with the exception
of one comorbid patient) neither the depressed nor the comorbid patients
met criteria for bipolar illness. In particular, comorbid patients with
primary depression and secondary alcoholism may tend to be "trimorbid",
with symptoms of depression, anxiety, and alcoholism. Furthermore, the
increased anxiety and irritability experienced by the comorbid patients may
contribute to their tendency to abuse alcohol.
In conjunction with the above project, we developed a questionnaire to
study patients' use of alcohol, carbohydrates, and caffeine in response to
specific depressive symptoms. The questionnaire has been administered to
patients with seasonal affective disorder, nonseasonal affective disorder,
primary depression with secondary alcohol dependence, alcohol dependence
without affective disorder, and normals. The data is currently being
analyzed to establish test-retest reliability, and to ascertain differences
between the groups in their use of these substances.
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会议论文
CHRONOBIOLOGICAL EVALUATION OF RAPID-CYCLING BIPOLAR DISORDER
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批准号:2578775
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
EVALUATION AND TREATMENT OF RAPID-CYCLING BIPOLAR DISORDER
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批准号:3781488
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
A CONTROLLED TRIAL OF PHOTOTHERAPY IN RAPID-CYCLING BIPOLAR DISORDER
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批准号:3759546
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
A CONTROLLED TRIAL OF PHOTOTHERAPY IN RAPID-CYCLING BIPOLAR DISORDER
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批准号:5203827
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
A CONTROLLED STUDY OF THE ANTIDEPRESSANT EFFICACY OF SLEEP DEPRIVATION
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批准号:3880992
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
CHRONOBIOLOGICAL EVALUATION OF RAPID-CYCLING BIPOLAR DISORDER
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批准号:5203775
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
A CONTROLLED STUDY OF THE ANTIDEPRESSANT EFFICACY OF SLEEP DEPRIVATION
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批准号:3859974
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
EVALUATION AND TREATMENT OF RAPID-CYCLING BIPOLAR DISORDER
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批准号:3845392
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
AN INVESTIGATION OF PRIMARY DEPRESSIVES WITH SECONDARY ALCOHOLISM
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批准号:3880991
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
CHRONOBIOLOGICAL EVALUATION OF RAPID-CYCLING BIPOLAR DISORDER
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批准号:6162896
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
CIRCADIAN INTERVENTIONS IN PATIENTS WITH RAPID-CYCLING BIPOLAR DISORDER
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批准号:2578819
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
A CONTROLLED STUDY OF THE ANTIDEPRESSANT EFFICACY OF SLEEP DEPRIVATION
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批准号:3845301
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
CIRCADIAN INTERVENTIONS IN PATIENTS WITH RAPID-CYCLING BIPOLAR DISORDER
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批准号:6162923
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
CHRONOBIOLOGICAL EVALUATION OF RAPID-CYCLING BIPOLAR DISORDER
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批准号:6111161
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
AN INVESTIGATION OF PRIMARY DEPRESSIVES WITH SECONDARY ALCOHOLISM
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批准号:3845300
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
CHRONOBIOLOGICAL EVALUATION OF RAPID-CYCLING BIPOLAR DISORDER
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批准号:3759493
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E LEIBENLUFT
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依托单位:
海外基金