AN INVESTIGATION OF PRIMARY DEPRESSIVES WITH SECONDARY ALCOHOLISM
AN INVESTIGATION OF PRIMARY DEPRESSIVES WITH SECONDARY ALCOHOLISM
批准号:
3859973
负责人:
E LEIBENLUFT
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
酒精依赖与严重精神疾病的共病
英文摘要
The comorbidity of alcohol dependence with major psychiatric illness,
including affective disorders, is receiving increased attention in the
psychiatric literature. However, little systematic research has been done
on patients with primary depression and secondary alcoholism. These
patients, who typically claim to "self-medicate" their depression with
alcohol, are interesting to study because their choice of psychoactive
substance may provide a clue to the neurochemistry underlying their
symptoms. During this period, we completed a pilot study comparing
patients with a history of comorbid primary depression and secondary
alcohol dependence to two comparison groups: patients with a history of
depression but no history of alcohol abuse or dependence, and patients with
a history of alcohol dependence but no affective illness. Patients were
matched according to age, sex, and Global Assessment of Functioning score.
Eleven patients in each group completed a standardized work-up in which we
characterized symptoms, family history, and pattern of drug and alcohol
abuse. Results indicate that comorbid patients are significantly more
likely than depressed patients to meet DSM-III-R criteria for panic
disorder (p=0.04). Compared to depressed patients, comorbid patients have
significantly higher hypomania scores (p=0.03) although (with the exception
of one comorbid patient) neither the depressed nor the comorbid patients
met criteria for bipolar illness. In particular, comorbid patients with
primary depression and secondary alcoholism may tend to be "trimorbid",
with symptoms of depression, anxiety, and alcoholism. Furthermore, the
increased anxiety and irritability experienced by the comorbid patients may
contribute to their tendency to abuse alcohol.
In conjunction with the above project, we developed a questionnaire to
study patients' use of alcohol, carbohydrates, and caffeine in response to
specific depressive symptoms. The questionnaire has been administered to
patients with seasonal affective disorder, nonseasonal affective disorder,
primary depression with secondary alcohol dependence, alcohol dependence
without affective disorder, and normals. The data is currently being
analyzed to establish test-retest reliability, and to ascertain differences
between the groups in their use of these substances.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
CHRONOBIOLOGICAL EVALUATION OF RAPID-CYCLING BIPOLAR DISORDER
-
批准号:2578775
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
A CONTROLLED TRIAL OF PHOTOTHERAPY IN RAPID-CYCLING BIPOLAR DISORDER
-
批准号:3759546
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
A CONTROLLED TRIAL OF PHOTOTHERAPY IN RAPID-CYCLING BIPOLAR DISORDER
-
批准号:5203827
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
EVALUATION AND TREATMENT OF RAPID-CYCLING BIPOLAR DISORDER
-
批准号:3781488
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
A CONTROLLED STUDY OF THE ANTIDEPRESSANT EFFICACY OF SLEEP DEPRIVATION
-
批准号:3880992
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
EVALUATION AND TREATMENT OF RAPID-CYCLING BIPOLAR DISORDER
-
批准号:3845392
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
AN INVESTIGATION OF PRIMARY DEPRESSIVES WITH SECONDARY ALCOHOLISM
-
批准号:3880991
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
CHRONOBIOLOGICAL EVALUATION OF RAPID-CYCLING BIPOLAR DISORDER
-
批准号:5203775
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
A CONTROLLED STUDY OF THE ANTIDEPRESSANT EFFICACY OF SLEEP DEPRIVATION
-
批准号:3859974
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
CHRONOBIOLOGICAL EVALUATION OF RAPID-CYCLING BIPOLAR DISORDER
-
批准号:6162896
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
CIRCADIAN INTERVENTIONS IN PATIENTS WITH RAPID-CYCLING BIPOLAR DISORDER
-
批准号:2578819
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
A CONTROLLED STUDY OF THE ANTIDEPRESSANT EFFICACY OF SLEEP DEPRIVATION
-
批准号:3845301
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
CHRONOBIOLOGICAL EVALUATION OF RAPID-CYCLING BIPOLAR DISORDER
-
批准号:6111161
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
CIRCADIAN INTERVENTIONS IN PATIENTS WITH RAPID-CYCLING BIPOLAR DISORDER
-
批准号:6162923
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
AN INVESTIGATION OF PRIMARY DEPRESSIVES WITH SECONDARY ALCOHOLISM
-
批准号:3845300
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
CHRONOBIOLOGICAL EVALUATION OF RAPID-CYCLING BIPOLAR DISORDER
-
批准号:3759493
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:E LEIBENLUFT
-
依托单位:
海外基金