Defining the role of Nlrp1 and the inflammasome in host defence and inflammatory disease

免疫系统保护身体免受入侵的病原体，但它也可以攻击身体，引起炎症和自身免疫性疾病，如关节炎和多发性硬化症。该项目将侧重于炎症反应的分子调控，炎症反应是一种感知入侵病原体并引发免疫反应的蛋白质复合物。了解炎性小体可能是更好地理解免疫系统的好功能和坏功能如何平衡以预防疾病的关键。

The immune system protects the body from invading pathogens, but it can also attack the body causing inflammatory and autoimmune diseases like arthritis and multiple sclerosis. This project will focus on the molecular regulation of the ïinflammasomeÍ, a protein complex that senses invading pathogens and triggers the immune response. Understanding the inflammasome may hold the key to a better understanding of how the good and bad functions of the immune system can be balanced to prevent disease.