Defining the role of Nlrp1 and the inflammasome in host defence and inflammatory disease

定义 Nlrp1 和炎症小体在宿主防御和炎症性疾病中的作用

• 批准号: nhmrc : 1002426
• 负责人: Dr Ben Croker
• 金额: $ 42.31万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-role-nlrp1-inflammatory-disease/108810
• 关键词: Defining; role; Nlrp1; inflammasome; host

The immune system protects the body from invading pathogens, but it can also attack the body causing inflammatory and autoimmune diseases like arthritis and multiple sclerosis. This project will focus on the molecular regulation of the ïinflammasomeÍ, a protein complex that senses invading pathogens and triggers the immune response. Understanding the inflammasome may hold the key to a better understanding of how the good and bad functions of the immune system can be balanced to prevent disease.

免疫系统保护身体免受入侵病原体的侵袭，但它也可以攻击身体，导致炎症和自身免疫性疾病，如关节炎和多发性硬化症。这个项目将专注于炎症体的分子调控，这是一种感知入侵病原体并触发免疫反应的蛋白质复合体。了解炎症小体可能是更好地理解免疫系统的好功能和坏功能如何平衡以预防疾病的关键。