Regulation of an IL-18 inflammasome by Wdr1

哺乳动物已经进化出一系列的机制来感知微生物。这些免疫哨兵必须区分自我和非自我，以激活免疫反应。免疫反应的启动、扩增和淬灭都经过精心安排，以消除入侵的病原体，同时最大限度地减少对宿主组织的附带损害。这项研究的重点是预防炎症性疾病，如心血管疾病，肝炎，炎症性肠病和皮肤病的蛋白质。

Mammals have evolved an array of mechanisms to sense microbes. These immune sentinels must distinguish self from non-self to activate an immune response. The initiation, amplification and quenching of an immune response is carefully orchestrated to eliminate invading pathogens while minimising collateral damage to host tissues. This research focuses on proteins that prevent inflammatory diseases such as cardiovascular disease, hepatitis, inflammatory bowel disease and skin diseases.