Regulation of an IL-18 inflammasome by Wdr1

Wdr1 对 IL-18 炎性体的调节

• 批准号: nhmrc : 1008131
• 负责人: Dr Ben Croker
• 金额: $ 24.04万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-an-il-inflammasome-wdr1/109283
• 关键词: Regulation; IL; 18; inflammasome; Wdr1

Mammals have evolved an array of mechanisms to sense microbes. These immune sentinels must distinguish self from non-self to activate an immune response. The initiation, amplification and quenching of an immune response is carefully orchestrated to eliminate invading pathogens while minimising collateral damage to host tissues. This research focuses on proteins that prevent inflammatory diseases such as cardiovascular disease, hepatitis, inflammatory bowel disease and skin diseases.

哺乳动物进化出了一系列感知微生物的机制。这些免疫哨兵必须区分自我和非我，才能激活免疫反应。免疫反应的启动、放大和猝灭经过精心策划，以消除入侵病原体，同时将对宿主组织的附带损害降至最低。这项研究的重点是预防心血管疾病、肝炎、炎症性肠病和皮肤病等炎症性疾病的蛋白质。