Pathogen sensing in autoinflammatory and autoimmune disease

自身炎症和自身免疫性疾病中的病原体传感

• 批准号: nhmrc : 637367
• 负责人: Dr Ben Croker
• 金额: $ 22.72万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathogen-sensing-autoinflammatory-autoimmune-disease/98726
• 关键词: Pathogen; sensing; autoinflammatory; autoimmune; disease

Mammals have evolved an array of mechanisms to sense microbes. These immune sentinels must distinguish self from non-self to activate an immune response. The initiation, amplification and quenching of an immune response is a carefully orchestrated process that eliminates invading pathogens while minimising collateral damage to host tissues. This research focuses on proteins that restrict immune responses to prevent inflammatory diseases such as rheumatoid arthritis and psoriasis.

哺乳动物已经进化出一系列的机制来感知微生物。这些免疫哨兵必须区分自我和非自我，以激活免疫反应。免疫反应的启动、扩增和淬灭是一个精心策划的过程，它消除了入侵的病原体，同时最大限度地减少了对宿主组织的附带损害。这项研究的重点是限制免疫反应的蛋白质，以防止炎症性疾病，如类风湿性关节炎和牛皮癣。