Defining the role of the PSA-related kallikrein serine proteases in hormone dependent cancer progression

激肽释放酶是与前列腺癌生物标志物PSA相关的15种蛋白质的家族，其具有作为激素依赖性癌症如前列腺癌和卵巢癌的生物标志物的潜力。Judith Clements教授和她的团队发现，激肽释放酶诱导卵巢癌对化疗的抵抗，并在前列腺癌骨病中发现。她的研究将确定激肽释放酶作用的潜在机制及其作为这些疾病的新生物标志物或治疗靶点的潜力。

Kallikreins are a family of 15 proteins, related to the prostate cancer biomarker PSA, that have potential as biomarkers for hormone dependent cancers such as prostate and ovarian cancer. Prof Judith Clements and her team discovered that kallikreins induce resistance to chemotherapy in ovarian cancer and are found in prostate cancer bone disease. Her research will determine the underlying mechanisms of kallikrein action and their potential as new biomarkers or treatment targets for these diseases.