Defining the role of the PSA-related kallikrein serine proteases in hormone dependent cancer progression

定义 PSA 相关激肽释放酶丝氨酸蛋白酶在激素依赖性癌症进展中的作用

• 批准号: nhmrc : 1005717
• 负责人: Prof Judith Clements
• 金额: $ 58.71万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-role-psa-cancer-progression/109107
• 关键词: Defining; role; PSA; related; kallikrein

Kallikreins are a family of 15 proteins, related to the prostate cancer biomarker PSA, that have potential as biomarkers for hormone dependent cancers such as prostate and ovarian cancer. Prof Judith Clements and her team discovered that kallikreins induce resistance to chemotherapy in ovarian cancer and are found in prostate cancer bone disease. Her research will determine the underlying mechanisms of kallikrein action and their potential as new biomarkers or treatment targets for these diseases.

激肽释放酶是与前列腺癌生物标志物PSA相关的15种蛋白质的家族，其具有作为激素依赖性癌症如前列腺癌和卵巢癌的生物标志物的潜力。Judith Clements教授和她的团队发现，激肽释放酶诱导卵巢癌对化疗的抵抗，并在前列腺癌骨病中发现。她的研究将确定激肽释放酶作用的潜在机制及其作为这些疾病的新生物标志物或治疗靶点的潜力。