In-depth association and functional studies assessing the role of novel single nucleotide polymorphisms in PSA and other Kallikrein genes in prostate cancer.

深入的关联和功能研究评估 PSA 和其他激肽释放酶基因中新型单核苷酸多态性在前列腺癌中的作用。

• 批准号: nhmrc : 1009458
• 负责人: Dr Jyotsna Batra
• 金额: $ 40.5万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/in-depth-association-prostate-cancer/109414
• 关键词: depth; association; functional; studies; assessing

The number of men diagnosed with prostate cancer varies substantially between races, indicating a role of genetics in prostate cancer development. Recently, we demonstrated that the genetic variations in the PSA gene are related to prostate cancer risk. We aim to elucidate the molecular mechanism of this correlation and to systematically investigate the association of novel genetic variations in other PSA related genes with prostate cancer risk in a search of sensitive clinical biomarkers for prostate cancer diagnosis and prognosis.

被诊断患有前列腺癌的男性人数在种族之间差异很大，表明遗传学在前列腺癌发展中的作用。最近，我们证明了PSA基因的遗传变异与前列腺癌的风险有关。我们的目的是阐明这种相关性的分子机制，并系统地研究其他PSA相关基因的新的遗传变异与前列腺癌风险的相关性，以寻找敏感的临床生物标志物用于前列腺癌的诊断和预后。