Systemic gene silencing in Arabidopsis, and relevance to plant biology

拟南芥中的系统基因沉默及其与植物生物学的相关性

• 批准号: DP150104048
• 负责人: Prof Bernard Carroll
• 金额: $ 24.49万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-24
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104048
• 关键词: Systemic; gene; silencing; Arabidopsis; relevance

Gene silencing is a highly conserved process in plants and animals. It is of fundamental importance to gene regulation, virus defence, genome response to environment, and genome evolution. Remarkably, when gene silencing is triggered in plants it can spread throughout the organism. The aim of this project is to define the mechanism of intercellular movement of gene silencing in plants, and its relevance to plant growth and defence against pathogens. Expected outcomes include increased understanding of intercellular genetic signalling in plants and its role in plant growth and disease resistance. The findings may also shed new light on mechanisms of gene silencing in animals.

基因沉默是植物和动物中高度保守的过程。它对基因调控、病毒防御、基因组对环境的反应和基因组进化具有根本的重要性。值得注意的是，当基因沉默在植物中被触发时，它可以在整个生物体中传播。该项目的目的是确定植物中基因沉默的细胞间运动机制及其与植物生长和防御病原体的相关性。预期成果包括加深对植物细胞间遗传信号及其在植物生长和抗病性中的作用的理解。这些发现也可能为动物基因沉默的机制提供新的线索。