PLASMA GABA--BIOLOGICAL MARKER FOR ALCOHOLISM

血浆 GABA——酗酒的生物标志物

• 批准号: 3110941
• 负责人: FREDERICK PETTY
• 金额: $ 6.84万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3110941
• 关键词: alcoholism /alcohol abuse; biomarker; cerebrospinal fluid; gamma aminobutyrate; high performance liquid chromatography; human middle age (35-64); human subject; interview; longitudinal human study; male; pathologic process; statistics /biometry; young adult human (21-34)

Gamma-amino butyric acid (GABA) is an inhibitory neurotransmitter which is thought to be involved in several neurological and psychiatric diseases. Although most GABA occurs in the central nervous system, small amounts of GABA are found in blood, and levels of plasma GABA may reflect its activity in brain. In several preliminary studies (supported in part by a NIMH Mental Health Small Grant) we have found levels of plasma GABA to be very low in recently detoxified patients with alcoholism, compared to controls and to patients with several other psychiatric diseases. The low plasma GABA levels were not correlated with several indices of severity of illness, such as amount of alcohol consumed, age, or duration of heavy drinking. Therefore, plasma GABA may represent a trait marker for the illness of alcoholism. We will test this hypothesis. First, a larger group of non-alcoholic controls will be studied to determine the stability of plasma GABA over time. Second, a series of patients with the diagnosis of alcoholism will have their plasma GABA levels determined on admission to an inpatient treatment unit, 28 days later at time of discharge, and on six month followup. A group of these patients will also have cerebrospinal fluid GABA measured to determine its correlation with plasma GABA. The hypothesis to be tested would predict that plasma GABA levels will remain low, even in those subjects who maintain sobriety. This research should contribute to our understanding of the role GABA plays in the pathophysiology of alcoholism

γ-氨基丁酸(GABA)是一种抑制性神经递质 被认为与几个神经学和精神病学有关 疾病。虽然大多数GABA发生在中枢神经系统，但很小 血液中存在大量的GABA，血浆中GABA的水平可能反映 它在大脑中的活动。 在几项初步研究中(部分得到NIMH心理健康的支持 我们发现血浆中的GABA水平非常低 近期戒毒的酒精中毒患者与对照组和 患有其他几种精神疾病的患者。低血浆GABA 水平与疾病严重程度的几个指数没有相关性， 例如饮酒量、年龄或酗酒时间。 因此，血浆GABA可能是糖尿病发病的一个特征标记物。 酗酒。 我们将检验这一假设。首先，一大群不酗酒的人 将进行对照研究，以确定血浆中GABA的稳定性 时间到了。其次，一系列被诊断为酗酒的患者将 在住院患者入院时测定他们的血浆GABA水平 治疗单元，出院时28天，6个月 后续行动。其中一组患者还将接受脑脊液治疗 测定GABA，以确定其与血浆GABA的相关性。这个 有待检验的假设将预测血浆GABA水平将保持不变 低，即使在那些保持清醒的受试者中也是如此。 这项研究将有助于我们理解GABA的作用 在酒精中毒病理生理学中的作用