Defining the roles and targeting interferon-epsilon as a new therapy for influenza in asthma and COPD

定义干扰素-ε作为治疗哮喘和慢性阻塞性肺病流感的新疗法的作用并靶向干扰素-ε

• 批准号: nhmrc : 1138004
• 负责人: A/Pr Aeron Hurt
• 金额: $ 61.25万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-roles-targeting-asthma-copd/1318639
• 关键词: Defining; roles; targeting; interferon; epsilon

Influenza is a major cause of illness and death, especially in people with asthma and emphysema. There are issues with vaccines and current treatments are poorly effective. Effective treatments are urgently required. We have found a new immune factor, interferon-epsilon that is induced and used by influenza viruses to cause infection. We aim to understand how this occurs and to test new treatments for influenza that suppress interferon-epsilon, in healthy and susceptible individuals.

流感是疾病和死亡的主要原因，特别是在哮喘和肺气肿患者中。疫苗存在问题，目前的治疗方法效果不佳。迫切需要有效的治疗方法。我们发现了一种新的免疫因子，干扰素-epsilon，它是由流感病毒诱导并利用来引起感染的。我们的目标是了解这种情况是如何发生的，并在健康和易感人群中测试抑制干扰素-epsilon的流感新疗法。