PATHOPHYSIOLOGY OF DISTAL SENSORY PERIPHERAL NEUROPATHY (DSPN) OF AIDS

艾滋病远端感觉周围神经病变（DSPN）的病理生理学

• 批准号: 3887350
• 负责人: FREDERICK T KOSTER
• 金额: --
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3887350
• 关键词: AIDS; edema; hereditary sensory neuropathy; human subject; magnetic resonance imaging; medical complication; nervous system disorder diagnosis; neural transmission

DSPN of AIDS appears to be a drying back neuropathy, similar to that of diabetes. Preliminary evidence indicates an increase in endoneurial water present in the early stages of disease, and we hypothesize that nerve edema contribute to the pathogenesis of nerve injury. We propose to quantitate nerve water by magnetic resonance spectroscopy, and compare these results with nerve conduction velocity and physical exam.

艾滋病的DSPN似乎是一种干燥性背部神经病，类似于 糖尿病 初步证据显示神经内水增加 出现在疾病的早期阶段，我们假设神经 水肿参与神经损伤的发病机制。 我们建议 通过磁共振波谱定量神经水，并比较 这些结果与神经传导速度和身体检查。