CISAPRIDE IN THE TREATMENT OF GASTROINTESTINAL MOTOR DYSFUNCTION

西沙必利治疗胃肠运动功能障碍

• 批准号: 3888140
• 负责人: WILLIAM E. WHITEHEAD
• 金额: --
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3888140
• 关键词: biomedical equipment resource; clinical biomedical equipment; constipation; gastrointestinal disorder chemotherapy; gastrointestinal motility /pressure; human subject; human therapy evaluation; irritable bowel syndrome; patient monitoring device

The aims of this study are (1) to develop and validate an ambulatory monitor to perform continuous monitoring of colon motility from 3 sites for 24-hour periods, (2) to compare patients with constipation-predominant irritable bowel syndrome to normal controls, and (3) to evaluate the efficacy of cisapride 20 mg Q.I.D. for symptoms of constipation-predominant IBS in a double-blind study.

本研究的目的是 (1) 开发和验证动态 监测器可对 3 个部位的结肠运动进行连续监测 24 小时周期，(2) 比较便秘为主的患者 肠易激综合征与正常对照相比，(3) 评估 西沙必利 20 mg Q.I.D. 的功效针对以便秘为主的症状 双盲研究中的肠易激综合症。