SELECTIVE IMMUNOSORPTION THERAPY IN HIGHLY SENSITIZED PATIENTS

高敏患者的选择性免疫吸附治疗

• 批准号: 3888086
• 负责人: EDGAR MILFORD
• 金额: --
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3888086
• 关键词: Staphylococcus; affinity chromatography; antibody; bacterial proteins; cyclophosphamide; histocompatibility; homologous transplantation; human subject; human therapy evaluation; human tissue; immunoglobulin G; immunosuppression; kidney transplantation; plasmapheresis

The purpose of this study was to demonstrate that a column of staph A protein conjugated to a solid state matrix is capable of selectively removing sufficient immunoglobulin to decrease the anti-HLA antibody which is found in highly sensitized dialysis patients who are awaiting a renal allograft. The reason for this is to ultimately develop a strategy for rendering a positive crossmatch (which precludes transplantation) negative, and in conjunction with oral immunosuppressive medication to prevent the recurrence of the anti-HLA.

本研究的目的是证明葡萄球菌A柱 与固态基质缀合的蛋白质能够选择性地 去除足够的免疫球蛋白以减少抗HLA抗体， 在等待肾移植的高致敏透析患者中发现 同种异体移植 这样做的原因是为了最终制定一项战略， 呈现阳性交叉配型（排除移植） 阴性，并结合口服免疫抑制药物， 防止抗HLA抗体的复发。