SELECTIVE IMMUNOSORPTION THERAPY IN HIGHLY SENSITIZED PATIENTS

高敏患者的选择性免疫吸附治疗

• 批准号: 3907501
• 负责人: EDGAR MILFORD
• 金额: --
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3907501
• 关键词: Staphylococcus; affinity chromatography; antibody; antileukocyte isoantibody; bacterial proteins; cyclophosphamide; homologous transplantation; human subject; human therapy evaluation; human tissue; immunoglobulin G; immunosuppression; immunosuppressive antileukocyte serum; kidney transplantation; plasmapheresis

The purpose of this protocol is to remove the IgG antibody, using an extracorporeal device consisting of a plasma separator and columns containing staph protein a coupled to sepharose. The goal is to remove the IgG antibody against the donor, return the residual plasma proteins to the patient, and prevent resynthesis of the anti-donor antibody with modest doses of cyclophosphamide. If levels of anti-donor antibody remain low over time and crossmatch is negative, renal transplant will be done.

该方案的目的是通过使用一种 由血浆分离器和柱子组成的体外装置 含有与琼脂糖偶联的葡萄球菌蛋白a。我们的目标是移除 针对供体的抗体，返回残留的血浆蛋白 并防止抗供体抗体的重新合成 适量的环磷酰胺。如果抗供体抗体水平保持不变 随着时间的推移，如果交叉配型为阴性，则将进行肾移植。