Defining the unifying mechanisms of oxidative damage to oligodendrocyte DNA in neurotrauma, neurodegenerative and demyelinating disease

定义神经外伤、神经退行性和脱髓鞘疾病中少突胶质细胞 DNA 氧化损伤的统一机制

• 批准号: nhmrc : GNT1160691
• 金额: $ 124.51万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-unifying-mechanisms-demyelinating-disease/1379138
• 关键词: Defining; unifying; mechanisms; oxidative; damage

Damage following injury to the central nervous system, and in Alzheimer’s Disease and Multiple sclerosis is similar and may be triggered by loss of the insulation around nerve cells, called myelin. We aim to identify a common mechanism by which the myelinating cells die and function is lost in the three conditions, enabling us to design a treatment that may be effective across the spectrum of injury and disease in the central nervous system.

中枢神经系统损伤后的损害，以及阿尔茨海默病和多发性硬化症是相似的，可能是由神经细胞周围的绝缘损失引发的，称为髓鞘。我们的目标是确定一种共同的机制，通过这种机制，髓鞘细胞死亡，功能在这三种情况下丧失，使我们能够设计一种治疗方法，这种治疗方法可能对中枢神经系统的损伤和疾病都有效。