PULMONARY SCOR--CORRELATED STUDIES OF PULMONARY FIBROSIS

佛蒙特州肺脏SCOR已经开发出一种协调的， 全面、系统的机制研究方法 肺间质重塑。这涉及到 前沿研究技术的多学科应用 从细胞和分子生物学到复杂的病人诊断， 管理和护理。计划的目标是定义器官、组织 和细胞功能被参与其中的特定试剂修饰 职业性和免疫性肺病病原学的改进 诊断、管理和治疗的科学依据。 对特定人类间质性疾病的研究将集中在 发育期和终末期疾病的组织和细胞病理学。 二氧化硅和石棉介导的动物模型的平行研究 肺损伤将集中在连接损伤的事件上， 炎症和最终的组织重塑。最后，具体 细胞培养和共培养系统将被用于探索 重塑过程的细胞生物学，因为它与 血管和间质。研究将确定 与之相关的致病途径数量有限 趋化、免疫介质如IL-1和巨噬细胞 生长因子、关键淋巴细胞和成纤维细胞亚群， 成纤维细胞数量和基质输出的调节以及 血管内皮细胞和平滑肌细胞的相互作用。特定的 从我们的动物研究中得出的发现和假设 模型和Lund cell将继续应用于我们的目标 随着我们继续寻求新的治疗方法，患者群体 探讨其诊断和处理方法。这包括 灌洗液和细胞中矿物质含量的监测 长期接触史的标志物。这些研究是 在多学科、协作性和 垂直方法，将用于定义 一些精选的致病途径可导致肺 与职业性和免疫性肺部疾病相关的病理学。

The Vermont Pulmonary SCOR has developed a coordinated, comprehensive and systematic approach for studying mechanisms of pulmonary interstitial remodeling. This involves multidisciplinary applications of forefront research technologies from cell and molecular biology to sophisticated patient diagnosis, management and care. Program goals are to define organ, tissue and cell function as modified by specific agents involved in the etiology of occupational and immunologic lung disease to improve the scientific basis of diagnosis, management and treatment. Studies of specific human interstitial diseases will focus on the tissue and cellular pathology of developing and endpoint disease. Parallel studies of animal models of silica and asbestos mediated lung injury will focus on connecting the events of injury, inflammation and eventual tissue remodeling. Finally, specific cell culture and co-culture systems will be used to explore the cell biology of the remodeling process as it pertains to the vasculature and interstitium. Studies will define the roles of a limited number of pathogenic pathways concerned with chemotaxis, immune mediators such as IL-1 and macrophage growth factors, key lymphocyte and fibroblast cell subpopulations, modulation of fibroblast number and matrix output and the interactions of endothelial and smooth muscle cells. Specific findings and hypotheses developed from our studies of animal models and lund cells will continue to be applied to our targeted patient population as we continue to seek novel ways of approaching their diagnosis and management. This includes monitoring of the mineral content of lavage fluids and cells as markers of long-term exposure history. The studies are significant in terms of the multidisciplinary, collaborative and vertical approaches that will be used to define the importance of a selected number of etiologic pathways that lead to pulmonary pathology related to occupational and immunologic lung disease.