PULMONARY SCOR--CORRELATED STUDIES OF PULMONARY FIBROSIS

肺 SCOR--肺纤维化的相关研究

• 批准号: 3106387
• 负责人: ROBERT B LOW
• 金额: $ 152.17万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-12-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106387
• 关键词: density gradient ultracentrifugation; diagnostic respiratory lavage; occupational disease /disorder; pneumoconiosis; pollution related respiratory disorder; pulmonary fibrosis /granuloma

The Vermont Pulmonary SCOR has developed a coordinated, comprehensive and systematic approach for studying mechanisms of pulmonary interstitial remodeling. This involves multidisciplinary applications of forefront research technologies from cell and molecular biology to sophisticated patient diagnosis, management and care. Program goals are to define organ, tissue and cell function as modified by specific agents involved in the etiology of occupational and immunologic lung disease to improve the scientific basis of diagnosis, management and treatment. Studies of specific human interstitial diseases will focus on the tissue and cellular pathology of developing and endpoint disease. Parallel studies of animal models of silica and asbestos mediated lung injury will focus on connecting the events of injury, inflammation and eventual tissue remodeling. Finally, specific cell culture and co-culture systems will be used to explore the cell biology of the remodeling process as it pertains to the vasculature and interstitium. Studies will define the roles of a limited number of pathogenic pathways concerned with chemotaxis, immune mediators such as IL-1 and macrophage growth factors, key lymphocyte and fibroblast cell subpopulations, modulation of fibroblast number and matrix output and the interactions of endothelial and smooth muscle cells. Specific findings and hypotheses developed from our studies of animal models and lund cells will continue to be applied to our targeted patient population as we continue to seek novel ways of approaching their diagnosis and management. This includes monitoring of the mineral content of lavage fluids and cells as markers of long-term exposure history. The studies are significant in terms of the multidisciplinary, collaborative and vertical approaches that will be used to define the importance of a selected number of etiologic pathways that lead to pulmonary pathology related to occupational and immunologic lung disease.

佛蒙特州肺 SCOR 开发了一个协调的、 全面系统的机制研究方法 肺间质重塑。 这涉及到 前沿研究技术的多学科应用 从细胞和分子生物学到复杂的患者诊断， 管理和照顾。 计划目标是定义器官、组织 和细胞功能由参与的特定试剂改变 职业性和免疫性肺病的病因学有待改善 诊断、管理和治疗的科学依据。 对特定人类间质性疾病的研究将集中于 发展中疾病和终点疾病的组织和细胞病理学。 二氧化硅和石棉介导的动物模型的平行研究 肺损伤将侧重于连接损伤事件， 炎症和最终的组织重塑。 最后，具体 细胞培养和共培养系统将用于探索 重塑过程的细胞生物学，因为它涉及 脉管系统和间质。 研究将定义a的角色 与此相关的致病途径数量有限 趋化性、免疫介质如 IL-1 和巨噬细胞 生长因子、关键淋巴细胞和成纤维细胞亚群， 成纤维细胞数量和基质输出的调节 内皮细胞和平滑肌细胞的相互作用。 具体的 我们对动物的研究得出的发现和假设 模型和 Lund 单元将继续应用于我们的目标 随着我们不断寻求新的方法来治疗患者群体 接近他们的诊断和管理。 这包括 监测灌洗液和细胞的矿物质含量 长期暴露史的标志。 这些研究是 在多学科、协作和 将用于定义重要性的垂直方法 导致肺部疾病的选定数量的病因学途径 与职业性和免疫性肺病相关的病理学。