SCOR: OCCUPATIONAL AND IMMUNOLOGIC LUNG DISEASES

SCOR：职业性和免疫性肺病

• 批准号: 3106382
• 负责人: ROBERT B LOW
• 金额: $ 128.32万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-12-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106382
• 关键词: inflammation; pneumoconiosis; pollution related respiratory disorder; pulmonary fibrosis /granuloma

The Vermont Pulmonary SCOR has developed a coordinated, comprehensive and systematic approach for studying mechanisms of pulmonary interstitial remodeling. This involves multidisciplinary applications of forefront research technologies from cell and molecular biology to sophisticated patient diagnosis, management and care. Program goals are to define organ, tissue and cell function as modified by specific agents involved in the etiology of occupational and immunologic lung disease to improve the scientific basis of diagnosis, management and treatment. Studies of specific human interstitial diseases will focus on the tissue and cellular pathology of developing and endpoint disease. Parallel studies of animal models of silica and asbestos mediated lung injury will focus on connecting the events of injury, inflammation and eventual tissue remodeling. Finally, specific cell culture and co-culture systems will be used to explore the cell biology of the remodeling process as it pertains to the vasculature and interstitium. Studies will define the roles of a limited number of pathogenic pathways concerned with chemotaxis, immune mediators such as IL-1 and macrophage growth factors, key lymphocyte and fibroblast cell subpopulations, modulation of fibroblast number and matrix output and the interactions of endothelial and smooth muscle cells. Specific findings and hypotheses developed from our studies of animal models and lund cells will continue to be applied to our targeted patient population as we continue to seek novel ways of approaching their diagnosis and management. This includes monitoring of the mineral content of lavage fluids and cells as markers of long-term exposure history. The studies are significant in terms of the multidisciplinary, collaborative and vertical approaches that will be used to define the importance of a selected number of etiologic pathways that lead to pulmonary pathology related to occupational and immunologic lung disease.

佛蒙特州肺SCOR已经制定了一个协调， 机制研究的全面和系统方法 肺间质重塑的迹象 这涉及 前沿研究技术的多学科应用 从细胞和分子生物学到复杂的患者诊断， 管理和照顾。 计划目标是定义器官，组织 和细胞功能的改变， 职业性和免疫性肺病的病因，以改善 诊断、管理和治疗的科学依据。 特定人类间质性疾病的研究将集中在 发展中和终点疾病的组织和细胞病理学。 二氧化硅和石棉介导的动物模型的平行研究 肺损伤将集中于连接损伤事件， 炎症和最终的组织重塑。 最后，具体 细胞培养和共培养系统将用于探索 重塑过程的细胞生物学，因为它属于 脉管系统和结缔组织。 研究将确定一个 有限数量的致病途径与 趋化性、免疫介质如IL-1和巨噬细胞 生长因子，关键淋巴细胞和成纤维细胞亚群， 调节成纤维细胞数量和基质输出， 内皮细胞和平滑肌细胞的相互作用。 具体 从我们对动物的研究中得出的发现和假设 模型和隆德细胞将继续应用于我们的目标， 患者群体，因为我们继续寻求新的方法， 他们的诊断和管理。 这包括 监测灌洗液和细胞的矿物质含量， 长期暴露史的标志物。 这些研究 在多学科、协作和 垂直方法，将用于定义的重要性， 导致肺部感染的选定数量的病因学途径 与职业病和免疫性肺病有关的病理学。