PULMONARY SCOR--CORRELATED STUDIES OF PULMONARY FIBROSIS

SCOR已经制定了一个全面的，有组织的和系统的方法， 人肺纤维化发病机制的研究，涉及9 医学院5个不同系的不同教员和一个 工程、数学和商业学院的系 局 特别令人感兴趣的是纤维化肺疾病相关的 与吸烟和环境中无机微粒的接触有关。 一个主要的目标是表征临床和病理生理学表达， 在一个仔细描述的患者人群中的纤维化肺病。 对这种疾病的传统研究方法进行了补充， 新的方法可能为诊断和治疗提供新的机会 并通过查明病原体，采取合理的预防办法。 一 该计划的第二个主要目标是阐明细胞致病机制 通过研究肺细胞相互作用和与病因学 剂. SCOR的焦点是纤维化过程，因为它表达在 不同的疾病状态，假设这一过程有共同的 不同疾病的致病途径不同，尽管病因不同 剂.

The SCOR has developed a comprehensive, organized & systematic approach for the study of pathogenic mechanisms of human pulmonary fibrosis, involving 9 different faculty in 5 different departments in the College of Medicine and one department in the College of Engineering, Mathematics and Business Administration. Of particular interest are fibrotic lung diseases associated with cigarette smoking and environmental exposure to inorganic particulates. One major goal is to characterize the clinical and pathophysiological expression of fibrotic lung disease in a carefully described patient population. Traditional approaches to the study of this disease have been supplemented with novel approaches which may offer new opportunities for diagnosis and treatment and, by identifying causative agents, rational approaches to prevention. A second major goal of the Program is to elucidate cellular pathogenic mechanisms of fibrosis through the study of lung cell interactions and with etiologic agents. The focus of the SCOR is the fibrogenic process as it is expressed in different disease states, under the hypothesis that this process shares common pathogenic pathways in different diseases although caused by different etiologic agents.