PULMONARY SCOR--CORRELATED STUDIES OF PULMONARY FIBROSIS

SCOR制定了一套全面、有组织和系统的方法，用于 人肺纤维化发病机制的研究，涉及9个 医学院5个不同系的不同教员和1个 工程、数学和商业学院系 行政部门。尤其令人感兴趣的是与纤维化相关的肺部疾病。 吸烟和在环境中暴露于无机颗粒物。 一个主要的目标是确定临床和病理生理表现的特征。 在仔细描述的患者群体中，纤维性肺病的发病率。 研究这种疾病的传统方法已经得到了补充 可能为诊断和治疗提供新机会的新方法 并通过确定致病因素，采取合理的预防方法。一个 该计划的第二个主要目标是阐明细胞致病机制 通过研究肺细胞的相互作用和与病因学的关系来研究纤维化 探员们。SCOR的焦点是纤维化过程，因为它在 不同的疾病状态，在这个过程共享共同的假设下 不同疾病的致病途径不同，但病因不同 探员们。

The SCOR has developed a comprehensive, organized & systematic approach for the study of pathogenic mechanisms of human pulmonary fibrosis, involving 9 different faculty in 5 different departments in the College of Medicine and one department in the College of Engineering, Mathematics and Business Administration. Of particular interest are fibrotic lung diseases associated with cigarette smoking and environmental exposure to inorganic particulates. One major goal is to characterize the clinical and pathophysiological expression of fibrotic lung disease in a carefully described patient population. Traditional approaches to the study of this disease have been supplemented with novel approaches which may offer new opportunities for diagnosis and treatment and, by identifying causative agents, rational approaches to prevention. A second major goal of the Program is to elucidate cellular pathogenic mechanisms of fibrosis through the study of lung cell interactions and with etiologic agents. The focus of the SCOR is the fibrogenic process as it is expressed in different disease states, under the hypothesis that this process shares common pathogenic pathways in different diseases although caused by different etiologic agents.