FACE AND HEAD PAIN: EXPERIMENTAL AND CLINICAL STUDIES

面部和头部疼痛：实验和临床研究

• 批准号: 3107835
• 负责人: CHARLES E POLETTI
• 金额: $ 51.6万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-01-01 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3107835
• 关键词: neurophysiology; oral facial pain; pain

Pain refractory to routine diagnosis and treatment disables millions of people in the United States, with an estimated annual cost of 70 billion dollars. One of the largest groups disabled by pain consists of people suffering from orofacial and head pains. While this special subgroup remains inadequately studied and treated, recent scientific and technological advances now mandate an investigation focused on the distinctive clinical features of orofacial and head pain and their unique underlying basic mechanisms. We believe our large academic clinical and research hospital is presently particularly well-positioned to provide such an investigation focused on orofacial and head pain. Accordingly, different disciplines within our institution - Neurology, Neurological Surgery, Oral Surgery, Psychiatry, and Anesthesia - are now joined together to propose this integrated multidisciplinary basic and clinical science Program Project. This Program Project proposes four basic scientific animal models focused on the mechanisms subserving intractable orofacial pain. These four models have been designed to study overlapping links of the trigeminal system extending from the peripheral receptors and nerves to the brainstem, thalamus, and somatosensory cortex. Modern extra and intracellular electrophysiology techniques are proposed, along with immunohistochemistry and electron microscopy, to be applied in animal models and postmortem human tissue. These basic studies are aimed at providing fundamental biological clues to the disabling clinical syndromes. The complementing clinical investigation focuses on three syndromes of orofacial pain in adults: trigeminal neuralgia, myofascial orofacial pain, and atypical facial pain. Our hope is that by completing this comprehensive, integrated, and balanced Program Project our multidisciplinary pain group will reach our common goals which are to understand further the mechanisms subserving intractable pain, and thereby to improve health care, especially for people suffering from orofacial pain and headaches.

常规诊断和治疗无效的疼痛 美国有数百万人，估计每年 耗资700亿美元。 最大的残疾群体之一， 疼痛包括人们遭受口面部和头部疼痛。 虽然这一特殊的亚组仍然没有得到充分的研究， 现在治疗，最新的科学和技术进步 要求进行一项调查，重点是独特的临床 口面部和头部疼痛的特点及其独特的潜在 基本机制。 我们相信我们的大型学术临床和研究医院是 目前特别适合提供这种 调查集中在口面部和头部疼痛。 因此，委员会认为， 我们机构内的不同学科-神经病学， 神经外科、口腔外科、精神病学和麻醉学- 现在联合起来提出了一个综合的 多学科基础和临床科学计划项目。 本项目提出了四种基本的科学动物模型 集中在机制subserving顽固性口面疼痛。 这四个模型被设计用来研究重叠的链接 三叉神经系统从外周感受器 以及脑干、丘脑和躯体感觉皮层的神经。 现代细胞外和细胞内电生理技术 提出，沿着免疫组化和电子 显微镜，应用于动物模型和死后 人体组织 这些基础研究旨在提供 基本的生物学线索，以致残的临床综合征。 补充临床研究的重点是三个 成人口面疼痛综合征：三叉神经痛， 肌筋膜口面部疼痛和非典型面部疼痛。 我们希望，通过完成这一全面、综合、 我们的多学科疼痛小组 将实现我们的共同目标，即进一步了解 缓解顽固性疼痛的机制，从而改善 保健，特别是对遭受口面部疼痛的人 还有头痛